Volume 22, Number 11—November 2016
Dispatch
Group B Streptococcus Sequence Type 283 Disease Linked to Consumption of Raw Fish, Singapore
Priyanka Rajendram, Win Mar Kyaw, Yee Sin Leo
, Hanley J. Ho, Wen Kai Chen, Raymond Lin, De Partha Pratim, Hishamuddin Badaruddin, Brenda Ang, Timothy Barkham, and Angela Chow
, Hanley J. Ho, Wen Kai Chen, Raymond Lin, De Partha Pratim, Hishamuddin Badaruddin, Brenda Ang, Timothy Barkham, and Angela Chow
Table 1
Characteristics of patients with invasive group B Streptococcus ST283 or non-ST283 infections and controls, Singapore*
| Characteristic |
ST283,
n = 9 |
Non-ST283, n = 13 |
Controls,
n = 76 |
Comparison and p value |
||
| ST283 vs. non-ST283 |
ST283 vs. controls |
Non-ST283 vs. controls |
||||
| Demographic | ||||||
| Sampled during epidemiologic wk 25–29 | 8 (88.9) | 3 (23.1) | 37 (48.7) | <0.01 | 0.02 | 0.09 |
| Median age, y (IQR) | 59.4 (25–70) | 74 (46–88) | 77.5 (42–99) | 0.03 | 0.002 | 0.37 |
| Age < 65 y† | 7 (77.8) | 3 (23.1) | 18 (23.7) | 0.01 | <0.001 | 0.96 |
| Female sex† | 6 (66.7) | 6 (46.2) | 45 (59.2) | 0.34 | 0.67 | 0.38 |
| Chinese ethnicity† |
9 (100.0) |
11 (84.6) |
58 (76.3) |
0.22 |
0.10 |
0.51 |
| Concurrent condition | ||||||
| Diabetes mellitus† | 1 (11.1) | 5 (38.5) | 33 (43.4) | 0.16 | 0.06 | 0.74 |
| Malignancy† | 1 (11.1) | 1 (7.7) | 11 (14.5) | 0.78 | 0.78 | 0.51 |
| Cardiovascular disease† | 1 (11.1) | 4 (30.8) | 29 (38.2) | 0.28 | <0.01 | 0.61 |
| Renal disease† | 1 (11.1) | 2 (15.4) | 25 (32.9) | 0.77 | 0.18 | 0.20 |
| Liver disease† | 0 | 2 (15.4) | 5 (6.6) | 0.22 | 0.43 | 0.28 |
| Gastrointestinal disease† | 1 (11.1) | 2 (15.4) | 14 (18.4) | 0.77 | 0.59 | 0.79 |
| Respiratory disease† | 0 | 2 (15.4) | 16 (21.1) | 0.22 | 0.13 | 0.64 |
| Blood disorder† | 0 | 1 (7.7) | 28 (36.8) | 0.39 | 0.03 | 0.04 |
| Skin wound† | 0 | 2 (15.4) | 12 (15.8) | 0.22 | 0.20 | 0.97 |
| Charlson Comorbidity Score, median (range) | 0 (0–9) | 2 (0–7) | 3.5 (0–12) | 0.21 | 0.03 | 0.26 |
| Any concurrent condition | 3 (33.3) | 11 (84.6) | 69 (90.8) | 0.01 | <0.001 | 0.50 |
| Hospitalized during 6 mo before admission† |
2 (22.2) |
6 (46.2) |
31 (40.8) |
0.25 |
0.28 |
0.72 |
| Food history | ||||||
| Ate raw or undercooked fish <2 wk before admission† | 7 (77.8) | 0 | 3 (4.0) | <0.001 | <0.001 | 0.47 |
| Ate raw or undercooked beef <2 wk before admission† | 2 (22.2) | 0 | 0 | 0.07 | <0.001 | NC |
| Ate raw vegetables† | 1 (11.1) | 0 | 4 (5.3) | 0.22 | 0.48 | 0.40 |
| Ate raw eggs† |
0 |
0 |
13 (17.1) |
NC |
0.18 |
0.11 |
| Other exposure history | ||||||
| Fish-related activities (fishing, fish spa)† |
0 |
0 |
0 |
NC |
NC |
NC |
| Clinical presentation | ||||||
| Fever (temperature >38°C) | 7 (77.8) | 9 (69.2) | 23 (30.3) | 0.66 | <0.01 | <0.01 |
| Musculoskeletal pain | 7 (77.8) | 4 (30.8) | 20 (26.3) | 0.03 | <0.01 | 0.74 |
| Fever and musculoskeletal pain | 5 (55.6) | 3 (23.1) | 8 (10.5) | 0.12 | <0.001 | 0.20 |
| <2 d between symptom onset and admission | 4 (44.4) | 11 (84.6) | 39 (51.3) | 0.05 | 0.70 | 0.03 |
*Values are no. (%) unless otherwise indicated. Bold indicates statistical significance. IQR, interquartile range; NC, not calculable.
†Data collected by using questionnaire.
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Page updated: October 19, 2016
Page reviewed: October 19, 2016
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