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Volume 22, Number 11—November 2016
Dispatch

ESBL-Producing and Macrolide-Resistant Shigella sonnei Infections among Men Who Have Sex with Men, England, 2015

Piers MookComments to Author , Jacquelyn McCormick, Manpreet Bains, Lauren A. Cowley, Marie A. Chattaway, Claire Jenkins, Amy Mikhail, Gwenda Hughes, Richard Elson, Martin Day, Rohini Manuel, Jayshree Dave, Nigel Field1, Gauri Godbole1, Timothy J. Dallman2, and Paul Crook2
Author affiliations: Public Health England, London, UK (P. Mook, J. McCormick, M. Bains, L.A. Cowley, M.A. Chattaway, C. Jenkins, A. Mikhail, G. Hughes, R. Elson, M. Day, N. Field, G. Godbole, T. Dallman, P. Crook); Barts Health National Health Service Trust, London (R. Manuel, J. Dave); University College London, London (N. Field)

Main Article

Table 1

Results of the phenotypic antimicrobial drug resistance profile of 4 isolates of Shigella sonnei, England, 2015*

Isolate
ID MIC for antimicrobial drugs tested, mg/mL†
AMP AMC CTX CRO CAZ CFP GEN TOB TMP SEP ATM CIP COL ERT MER FOS TEM AZT
182834 >1,052 1 >32 >32 2 0.38 0.5 0.38 >32 64 0.38 <0.032 0.19 0.008 0.06 1 <1 >256
184494 >1,052 1 >32 >32 2 0.5 0.38 0.38 >32 128 0.5 <0.032 0.125 0.008 0.06 1.5 <1 >256
183660 >1,052 1 >32 >32 1 0.38 0.38 0.38 >32 128 0.38 <0.032 0.125 0.008 0.06 1 <1 >256
164679 >1,052 1 >32 >32 1 0.38 0.38 0.38 >32 64 0.38 <0.032 0.19 0.008 0.06 1 <1 >256

*TEM was included in the panel to aid detection of OXA-48–like carbapenemases. AMC, amoxicillin/clavulanate; AMP, ampicillin; ATM, aztreonam; AZT, azithromycin; CAZ, ceftazidime; CFP, cefepime; CIP, ciprofloxacin; COL, colistin; CRO, ceftriaxone; CTX, cefotaxime; ERT, ertapenem; FOS, fosfomycin; GEN, gentamicin; ID, identification; MER, meropenem; SEP, trimethoprim/sulfamethoxazole; TEM, temocillin; TMP, trimethoprim; TOB, tobramycin.
†Phenotypic antimicrobial drug susceptibility testing was performed by using Etest (bioMérieux, Marcy l’Etoile, France) and interpreted by using breakpoints for Enterobacteriaceae established by the European Committee on Antimicrobial Susceptibility Testing (http://www.eucast.org/). Production of extended-spectrum β-lactamase was confirmed by using CTX + clavulunic acid and CAZ + clavalunic acid in combination (bioMérieux).

Main Article

1These authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: October 19, 2016
Page updated: October 19, 2016
Page reviewed: October 19, 2016
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