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Volume 22, Number 11—November 2016
Dispatch

Early Growth and Neurologic Outcomes of Infants with Probable Congenital Zika Virus Syndrome

Antonio Augusto Moura da SilvaComments to Author , Jucelia Sousa Santos Ganz, Patricia da Silva Sousa, Maria Juliana Rodvalho Doriqui, Marizelia Rodrigues Costa Ribeiro, Maria dos Remédios Freitas Carvalho Branco, Rejane Christine de Sousa Queiroz, Maria de Jesus Torres Pacheco, Flavia Regina Vieira da Costa, Francelena de Sousa Silva, Vanda Maria Ferreira Simões, Marcos Antonio Barbosa Pacheco, Fernando Lamy-Filho, Zeni Carvalho Lamy, and Maria Teresa Seabra Soares de Britto e Alves
Author affiliations: Federal University of Maranhão, Sao Luis, Maranhão, Brazil (A.A.M. Silva, M.R.C. Ribeiro, M.R.F.C. Branco, R.C.S. Queiroz, M.J.T. Pacheco, V.M.F. Simões, F. Lamy-Filho, Z.C. Lamy, M.T.S.S.B. Alves); State Department of Health of Maranhão, Sao Luis, Maranhão (J.S.S. Ganz, P.S. Sousa, M.J.R. Doriqui, F.R.V. da Costa, F.S. Silva, M.A.B. Pacheco)

Main Article

Table

Clinical characteristics of probable congenital Zika virus syndrome in infants from birth to 1–8 months of age, Sao Luis, Brazil, 2015–2016

Characteristic
No. (%)
Rash in mother during pregnancy, n = 46
First trimester 24 (52.2)
First month 1 (2.2)
Second month 12 (26.1)
Third month 11 (23.9)
Second trimester 10 (21.7)
Fourth month 9 (19.6)
Sixth month 1 (2.2)
No rash
12 (26.1)
Sex, n = 48
M 25 (52.1)
F
23 (47.9)
Gestational age at birth, n = 47
Preterm 4 (8.5)
Term 41 (87.2)
Postterm
2 (4.3)
Head circumference z-score at birth,* n = 45
>–2 6 (13.3)
Microcephaly, <–2 10 (22.2)
Severe microcephaly, <–3
29 (64.5)
Birth length z-score,* n = 3
>–2 21 (56.8)
<–2 11 (29.7)
<–3
5 (13.5)
Birthweight z-score,* n = 46
>–2 37 (80.4)
<–2 8 (17.4)
<–3
1 (2.2)
Age at last visit, mo, n = 48
1 2 (4.2)
2 6 (12.5)
3 7 (14.6)
4 10 (20.8)
5 10 (20.8)
6 7 (14.6)
7 5 (10.4)
8
1 (2.1)
Phenotype, n = 48
Craniofacial disproportion 46 (95.8)
Biparietal depression 40 (83.3)
Prominent occiput 36 (75.0)
Excess nuchal skin
23 (47.9)
Signs and symptoms, n = 48
Irritability 41 (85.4)
Pyramidal/extrapyramidal syndrome 27 (56.3)
Epileptic seizures 24 (50.0)
Dysphagia 7 (14.6)
Congenital clubfoot 5 (10.4)
Arthrogryposis 5 (10.4)
Cleft lip/cleft palate
1 (2.1)
Electroencephalogram findings, n = 27
Abnormal activity, no epileptiform discharges 13 (48.1)
Focal epileptiform discharges 8 (29.6)
Multifocal epileptiform discharges
6 (22.2)
Cranial computed tomography imaging findings, n = 48
Calcifications in the brain parenchyma 44 (91.7)
Malformation of cortical development 42 (87.5)
Ventriculomegaly 37 (77.1)
White matter attenuation 15 (31.3)
Brain stem and cerebellum hypoplasia 6 (12.5)

*Reported as deviations of the raw z-score from the mean measured in SD units.

Main Article

Page created: October 19, 2016
Page updated: October 19, 2016
Page reviewed: October 19, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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