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Volume 22, Number 12—December 2016
Research

Vertebrate Host Susceptibility to Heartland Virus

Angela M. Bosco-Lauth, Amanda E. Calvert, J. Jeffrey Root, Tom Gidlewski, Brian H. Bird, Richard A. Bowen, Atis Muehlenbachs, Sherif Zaki, and Aaron C. BraultComments to Author 
Author affiliations: Centers for Disease Control and Prevention, Fort Collins, Colorado, USA (A.M. Bosco-Lauth, A.E. Calvert, A.C. Brault); Colorado State University; Fort Collins (A.M. Bosco-Lauth, R.A. Bowen); US Department of Agriculture, Fort Collins (J.J. Root, T. Gidlewski); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (B.H. Bird, A. Muehlenbachs, S.R. Zaki)

Main Article

Figure 2

Pathologic changes associated with infection of interferon-α/β/γ receptor–deficient (Ag129) mice with Heartland virus (HRTV). A) Mouse showing typical clinical signs of HRTV infection (ruffled fur, hunched posture, and squinting eyes). B) Dissected mouse showing an enlarged pale spleen (arrow). C–E) Hematoxylin and eosin staining (left panels) and immunohistochemical staining (right panels) for HRTV nucleocapsid protein of spleen (C), liver (D), and kidney (E) of Ag129 mice at 5–7 days postinocu

Figure 2. Pathologic changes associated with infection of interferon-α/β/γ receptor–deficient (Ag129) mice with Heartland virus (HRTV). A) Mouse showing typical clinical signs of HRTV infection (ruffled fur, hunched posture, and squinting eyes). B) Dissected mouse showing an enlarged pale spleen (arrow). C–E) Hematoxylin and eosin staining (left panels) and immunohistochemical staining (right panels) for HRTV nucleocapsid protein of spleen (C), liver (D), and kidney (E) of Ag129 mice at 5–7 days postinoculation with 104 PFU virus. Original magnifications: C, ×100; D, ×50; E, ×100.

Main Article

Page created: November 17, 2016
Page updated: November 17, 2016
Page reviewed: November 17, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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