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Volume 22, Number 2—February 2016

Randomized Controlled Trial of Hospital-Based Hygiene and Water Treatment Intervention (CHoBI7) to Reduce Cholera

Christine Marie GeorgeComments to Author , Shirajum Monira, David A. Sack, Mahamud-ur Rashid, K.M. Saif-Ur-Rahman, Toslim Mahmud, Zillur Rahman, Munshi Mustafiz, Sazzadul Islam Bhuyian, Peter J. Winch, Elli Leontsini, Jamie Perin, Farzana Begum, Fatema Zohura, Shwapon Biswas, Tahmina Parvin, Xiaotong Zhang, Danielle Jung, R. Bradley Sack, and Munirul Alam
Author affiliations: Johns Hopkins University, Baltimore, Maryland, USA (C.M. George, D.A. Sack, P.J. Winch, E. Leontsini, J. Perin, X. Zhang, D. Jung, R.B. Sack); icddr,b, Dhaka, Bangladesh (S. Monira, M. Rashid, K.M. Saif-Ur-Rahman, T. Mahmud, Z. Rahman, M. Mustafiz, S.I. Bhuyian, F. Begum, F. Zohura, S. Biswas, T. Parvin, M. Alam)

Main Article

Table 2

Evaluation of intervention efficacy to reduce Vibrio cholerae infection among household contacts of cholera patients during the intervention period (visits 2–5), Dhaka, Bangladesh, June 2013–November 2014

Household contact characteristic No. (%) contacts
Odds ratio (95% CI) p value*
Control arm Intervention arm
Culture results available 160 (100) 160 (100)
Negative for V. cholerae infection at baseline 148 (93) 140 (88) 1.15 (0.88–1.51) 0.30
Initial V. cholerae infections during the intervention period 20 (14) 10 (7) 0.50 (0.21–1.18) 0.11
Initial symptomatic V. cholerae infections during intervention period† 8 (5) 0 0.00 (0–0.623)‡ 0.006§

*Calculated with logistic regression model by using generalized estimating equations to account for clustering within study households.
†Symptomatic infection defined as a V. cholerae–infected household contact with diarrhea or vomiting in the past 48 hours.
‡To calculate exact 95% CIs, an algorithm was used to invert household-level test statistics.
§Fisher exact test calculated at the household level.

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Page created: January 13, 2016
Page updated: January 13, 2016
Page reviewed: January 13, 2016
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