Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 22, Number 3—March 2016

Underestimation of Invasive Meningococcal Disease in Italy

Chiara Azzari1Comments to Author , Francesco Nieddu1, Maria Moriondo1, Giuseppe Indolfi, Clementina Canessa, Silvia Ricci, Leila Bianchi, Daniele Serranti, Giovanni Maria Poggi, and Massimo Resti
Author affiliations: Anna Meyer Children’s University Hospital, Florence (C. Azzari, F. Nieddu, M. Moriondo, G. Indolfi, C. Canessa, S. Ricci, L. Bianchi, D. Serranti, G.M. Poggi, M. Resti); University of Florence Department of Health Sciences, Florence, Italy (C. Azzari, F. Nieddu, M. Moriondo, S. Ricci, D. Serranti, G.M. Poggi)

Main Article

Table 3

Distribution of rPCR and culture-based test results for Neisseria meningitidis for CSF and blood samples from a national register for molecular surveillance of invasive bacterial disease, Italy, 2007–2014*

Type of sample No. samples/no. tested (%)
Positive by rPCR Negative by rPCR Not tested by rPCR Total†
Culture positive 33 0 0 33/90 (36.7)
Culture negative 55 2 0 57/90 (63.3)
Not tested with culture 72 0 0 0
160/162 (98.8)
2/162 (1.2)
Culture positive 16 0 10 26/107 (24.3)
Culture negative 37 10 34 81/107 (75.7)
Not tested with culture 51 2 0 0
104/116 (89.7)
12/116 (10.3)
Total, CSF or blood
Culture positive 49 0 10 59/197 (29.9)
Culture negative 92 12 34 138/197 (70.1)
Not tested with culture 123 2 0 0
Total 264/278 (95.0) 14/278 (5.0) 0 0

*A total of 162 CSF samples were tested with rPCR, and 90 were tested with culture-based methods. A total of 116 blood samples were tested with rPCR, and 107 were tested with culture-based methods. CSF, cerebrospinal fluid; rPCR, real-time PCR.
†Proportion of samples that were positive, negative, or not tested with culture-based methods.

Main Article

1These authors contributed equally to this article.

Page created: February 18, 2016
Page updated: February 18, 2016
Page reviewed: February 18, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.