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Volume 22, Number 3—March 2016
Dispatch

Signs or Symptoms of Acute HIV Infection in a Cohort Undergoing Community-Based Screening

Martin HoeniglComments to Author , Nella Green, Martha Camacho, Sara Gianella, Sanjay R. Mehta, Davey M. Smith, and Susan J. Little
Author affiliations: Medical University of Graz, Graz, Austria (M. Hoenigl); University of California San Diego, San Diego, California, USA (M. Hoenigl, N. Green, M. Camacho, S. Gianella, S.R. Mehta, D.M. Smith, S.J. Little); Veterans Affairs Healthcare System, San Diego (S.R. Mehta, D.M. Smith)

Main Article

Table 2

Signs or symptoms occurring in 69 persons with AHI, San Diego, California, USA, 2007–2014*

Characteristic
Signs/symptoms
p value
Signs/symptoms
p value
Compatible with AHI†
Resolved before NAT
Ongoing at NAT
Persons seeking medical attention
Persons not seeking medical attention
No. persons reporting symptoms 69 16 41 10 22
Duration of symptoms, d, median (IQR) 8 (5–11) 7 (4–8) 11 (7–13) <0.01 13 (10–17) 10 (4–11) 0.01
No. (%) persons with typical AHI
64 (93)
15 (94)
36 (86)
NS
10 (100)
18 (82)
NS
Signs or symptoms, no. (%)
Fever 53 (77) 11 (69) 34 (83) NS 9 (90) 16 (73) NS
Myalgia 48 (70) 13 (81) 28 (68) NS 8 (80) 12 (55) NS
Fatigue 48 (70) 13(81) 29 (71) NS 9 (90) 13 (59) NS
Headache 42 (61) 10 (63) 27 (66) NS 8 (80) 11 (50) NS
Night sweats 38 (55) 5 (31) 26 (63) 0.04 7 (70) 9 (41) NS
Pharyngitis 34 (49) 9 (56) 17 (41) NS 4 (40) 11 (50) NS
GI symptoms‡ 29 (42) 3 (19) 22 (54) 0.02 5 (50) 7 (32) NS
Rash 19 (28) 6 (38) 12 (29) NS 5 (50) 5 (23) NS
Weight loss§ 15 (22) 2 (13) 12 (29) NS 6 (60) 3 (14) 0.01
Arthralgia 14 (20) 3 (19) 8 (20) NS 4 (40) 1 (5) 0.02

*AHI, acute HIV infection; GI, gastrointestinal; IQR, interquartile range; NAT, nucleic acid amplification testing; NS, not significant.
†Defined as having started <4 days before estimated date of infection or after the estimated date of infection.
‡General GI symptoms (e.g., nausea, vomiting, and diarrhea).
§Weight loss >2.5 kg.

Main Article

Page created: February 18, 2016
Page updated: February 18, 2016
Page reviewed: February 18, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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