TY - JOUR AU - Börjesson, Stefan AU - Ny, Sofia AU - Egervärn, Maria AU - Bergström, Jakob AU - Rosengren, Åsa AU - Englund, Stina AU - Löfmark, Sonja AU - Byfors, Sara T1 - Limited Dissemination of Extended-Spectrum β-Lactamase– and Plasmid-Encoded AmpC–Producing Escherichia coli from Food and Farm Animals, Sweden T2 - Emerging Infectious Disease journal PY - 2016 VL - 22 IS - 4 SP - 634 SN - 1080-6059 AB - Extended-spectrum β-lactamase (ESBL)– and plasmid-encoded ampC (pAmpC)–producing Enterobacteriaceae might spread from farm animals to humans through food. However, most studies have been limited in number of isolates tested and areas studied. We examined genetic relatedness of 716 isolates from 4,854 samples collected from humans, farm animals, and foods in Sweden to determine whether foods and farm animals might act as reservoirs and dissemination routes for ESBL/pAmpC-producing Escherichia coli. Results showed that clonal spread to humans appears unlikely. However, we found limited dissemination of genes encoding ESBL/pAmpC and plasmids carrying these genes from foods and farm animals to healthy humans and patients. Poultry and chicken meat might be a reservoir and dissemination route to humans. Although we found no evidence of clonal spread of ESBL/pAmpC-producing E. coli from farm animals or foods to humans, ESBL/pAmpC-producing E. coli with identical genes and plasmids were present in farm animals, foods, and humans. KW - Escherichia coli KW - bacteria KW - antimicrobial resistance KW - extended-spectrum β-lactamase KW - ESBL KW - plasmid-encoded AmpC KW - pAmpC KW - foodborne infections KW - farm animals KW - meat KW - broilers KW - poultry KW - bloodstream infections KW - carriage KW - extended-spectrum cephalosporin KW - national assessment KW - Sweden KW - Food Safety DO - 10.3201/eid2204.151142 UR - https://wwwnc.cdc.gov/eid/article/22/4/15-1142_article ER - End of Reference