TY - JOUR AU - Chen, Huazhong AU - Liu, Shelan AU - Liu, Jun AU - Chai, Chengliang AU - Mao, Haiyan AU - Yu, Zhao AU - Tang, Yuming AU - Zhu, Geqin AU - Chen, Haixiao AU - Zhu, Chengchu AU - Shao, Hui AU - Tan, Shuguang AU - Wang, Qianli AU - Bi, Yuhai AU - Zou, Zhen AU - Liu, Guang AU - Jin, Tao AU - Jiang, Chengyu AU - Gao, George AU - Oh, Myoung-don AU - Wei, Sheng AU - Chen, Enfu T1 - Nosocomial Co-Transmission of Avian Influenza A(H7N9) and A(H1N1)pdm09 Viruses between 2 Patients with Hematologic Disorders T2 - Emerging Infectious Disease journal PY - 2016 VL - 22 IS - 4 SP - 598 SN - 1080-6059 AB - A nosocomial cluster induced by co-infections with avian influenza A(H7N9) and A(H1N1)pdm09 (pH1N1) viruses occurred in 2 patients at a hospital in Zhejiang Province, China, in January 2014. The index case-patient was a 57-year-old man with chronic lymphocytic leukemia who had been occupationally exposed to poultry. He had co-infection with H7N9 and pH1N1 viruses. A 71-year-old man with polycythemia vera who was in the same ward as the index case-patient for 6 days acquired infection with H7N9 and pH1N1 viruses. The incubation period for the second case-patient was estimated to be <4 days. Both case-patients died of multiple organ failure. Virus genetic sequences from the 2 case-patients were identical. Of 103 close contacts, none had acute respiratory symptoms; all were negative for H7N9 virus. Serum samples from both case-patients demonstrated strong proinflammatory cytokine secretion but incompetent protective immune responses. These findings strongly suggest limited nosocomial co-transmission of H7N9 and pH1N1 viruses from 1 immunocompromised patient to another. KW - H7N9 KW - cluster KW - human-to-human transmission KW - nosocomial transmission KW - immunocompromised KW - co-infection KW - pandemic KW - A(H1N1)pdm09 KW - A(H1N1)pdm2009 KW - pH1N1 KW - H1N1 KW - influenza KW - viruses KW - hematologic disorders KW - chronic lymphocytic leukemia KW - polycythemia vera KW - zoonoses DO - 10.3201/eid2204.151561 UR - https://wwwnc.cdc.gov/eid/article/22/4/15-1561_article ER - End of Reference