Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 22, Number 5—May 2016
Research

Differences in Genotype, Clinical Features, and Inflammatory Potential of Borrelia burgdorferi sensu stricto Strains from Europe and the United States

Tjasa Cerar1, Franc Strle1, Dasa Stupica, Eva Ruzic-Sabljic, Gail McHugh, Allen C. Steere, and Klemen StrleComments to Author 
Author affiliations: University of Ljubljana, Ljubljana, Slovenia (T. Cerar, E. Ruzic-Sabljic); University Medical Center, Ljubljana (F. Strle, D. Stupica); Massachusetts General Hospital, Boston, Massachusetts, USA (G. McHugh, A.S. Steere, K. Strle)

Main Article

Figure 3

Phylogenetic comparison of 3 major pathogenic Borrelia species (Borrelia afzelii , B. garinii, and B. burgdorferi sensu stricto) that cause Lyme borreliosis, Europe and the United States. A) Minimum spanning tree analysis of 474 B. burgdorferi sensu lato human isolates. Analysis included 404 previously published datasets available in the multilocus sequence typing database (http://pubmlst.org/borrelia/) as of May 5, 2015, and 70 B. burgdorferi sensu stricto isolates from this study. Circles and

Figure 3. Phylogenetic comparison of 3 major pathogenic Borrelia species (Borrelia afzelii, B. garinii, and B. burgdorferi sensu stricto) that cause Lyme borreliosis. A) Minimum spanning tree analysis of 474 B. burgdorferi sensu lato human isolates. Analysis included 404 previously published datasets available in the multilocus sequence typing database (http://pubmlst.org/borrelia/) as of May 5, 2015, and 70 B. burgdorferi sensu stricto isolates from this study. Circles and numbers indicate specific sequence types (STs). Sizes of circles indicate MLST sample size and colors indicate origin of isolates. Lengths of lines connecting STs indicate order of certainty. STs connected by the shortest line are single locus-variants. B) Bayesian consensus tree resulting from simultaneous analysis of concatenated sequences of housekeeping genes of 70 B. burgdorferi sensu stricto isolates included in this study, representative strains of B. afzelii (http://pubmlst.org/borrelia/id:1546), and B. garinii (http://pubmlst.org/ borrelia/id:1829). Values at nodes indicate Bayesian posterior probabilities (proportion of sampled trees containing the taxon bipartition). Scale bar indicates nucleotide substitutions per site.

Main Article

1These authors contributed equally to this article.

Page created: April 13, 2016
Page updated: April 13, 2016
Page reviewed: April 13, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external