Volume 22, Number 5—May 2016
Research
Differences in Genotype, Clinical Features, and Inflammatory Potential of Borrelia burgdorferi sensu stricto Strains from Europe and the United States
Tjasa Cerar1, Franc Strle1, Dasa Stupica, Eva Ruzic-Sabljic, Gail McHugh, Allen C. Steere, and Klemen Strle
Table 3
Clinical characteristics of erythema migrans patients infected with Borrelia afzelii, B. garinii, or B. burgdorferi sensu stricto in Slovenia and B. burgdorferi sensu stricto in the United States*
| B. afzelii, n = 200† | B. garinii, n = 116† | B. burgdorferi sensu stricto, n = 14 | |||
|---|---|---|---|---|---|
| General | |||||
| Age, y | 50 (15–79) | 54 (20–83) | 50 (3–77) | 49 (15–82) | 0.6 |
| Female sex | 128 (64) | 61 (53) | 10 (71) | 44 (49) | 0.2 |
| EM duration at study entry, d | 9 (1–206) | 5 (1–61) | 7 (2–53) | 4 (1–30) | 0.02 |
| EM diameter, cm |
13 (5–86) |
18 (5–72) |
12 (5–38) |
11 (5–56) |
0.6 |
| Symptoms at study entry | |||||
| Symptoms/patient | 0 (0–6) | 0 (0–7) | 0 (0–6) | 4 (0–9) | 0.005 |
| Patients with symptoms | 66 (33) | 43 (37) | 4 (29) | 70 (78) | <0.001 |
| Fatigue | 51 (26) | 23 (20) | 3 (21) | 55 (61) | 0.01 |
| Arthralgia | 30 (15) | 21 (18) | 3 (21) | 42 (47) | 0.1 |
| Myalgia | 28 (14) | 22 (19) | 3 (21) | 28 (32) | 0.7 |
| Headache | 27 (14) | 21 (18) | 4 (29) | 45 (50) | 0.2 |
| Fever, chills | 12 (6) | 10 (9) | 2 (14) | 41 (46) | 0.05 |
| Neck stiffness | 9 (5) | 4 (3) | 0 | 43 (48) | 0.002 |
| Malaise | 21 (11) | 21 (18) | 2 (14) | 47 (52) | 0.01 |
*Values are median (range) or no. (%). EM, erythema migrans.
†Based on previously published data: B. burgdorferi sensu stricto (10); B. afzelii (5); B. garinii (20).
‡For comparison of B. burgdorferi sensu stricto from Slovenia versus the United States. Values in bold indicate statistical significance.
1These authors contributed equally to this article.
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