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Volume 22, Number 5—May 2016
Letter

Fatal Sickle Cell Disease and Zika Virus Infection in Girl from Colombia

Laura Arzuza-Ortega, Arnulfo Polo, Giamina Pérez-Tatis, Humberto López-García, Edgar Parra, Lissethe C. Pardo-Herrera, Angélica M. Rico-Turca, Wilmer Villamil-Gómez, and Alfonso J. Rodríguez-Morales
Author affiliations: Entidades Promotoras de Salud Barrios Unido Mutual, Quibdó, Colombia (L. Arzuza-Ortega); Empresa Social del Estado Hospital de Malambo, Malambo, Colombia (A. Polo); Hospital Metropolitano, Barranquilla, Colombia (G. Pérez-Tatis, H. López-García); Instituto Nacional de Salud, Bogotá, Colombia (E. Parra, L.C. Pardo-Herrera, A.M. Rico-Turca); Hospital Universitario de Sincelejo, Sincelejo, Colombia, (W. Villamil-Gómez); Universidad del Atlántico, Barranquilla (W. Villamil-Gómez); Universidad de Cartagena, Cartagena, Colombia (W. Villamil-Gómez); Universidad Tecnológica de Pereira, Pereira, Colombia (A.J. Rodriguez-Morales)

Main Article

Table

Clinical laboratory results for 15-year-old girl with sickle cell disease who died of Zika virus infection, Colombia*

Laboratory test Baseline value Value at hospitalization (Malambo) Value 24 h later (ICU, Barranquilla)
Leukocyte count, × 109 cells/L 10.00 8.23 ND
Hemoglobin level, g/dL 7.00 8.10 4.20
Hematocrit, % 28.00 25.00 13.00
MCV, fL/erythrocyte 73.00 73.00 ND
Reticulocytes, % 1.00 1.00 ND
Total bilirubin, mg/dL ND 2.97 ND
Direct bilirubin, mg/dL ND 1.67 ND
Platelet count/mL
ND
54,000.00
76,000.00
PT, s ND ND 33.3 (control 13.10)
aPTT, s ND ND 45.0 (control 29.80)
ALT, mg/dL ND ND 2,245.00
AST, mg/dL ND ND 3,215.00
LDH , IU/L
ND
ND
441.00
Alkaline hemoglobin electrophoresis, %
HbS ND ND 62.50
HbC–E ND ND 37.50
HbF
ND
ND
0.00
Malaria thick and thin blood smears† Not done Not done
HIV-1 and HIV-2 ELISA† Not done Not done
MAT for Leptospira spp.†
Not done
Not done

RT-PCR for DENV† Not done Not done
RT-PCR for CHIKV† Not done Not done
RT-PCR for YFV† Not done Not done
RT-PCR for ZIKV† Not done Not done +

*ICU, intensive care unit; ND, not determined; MCV, mean corpuscular volume; PT, prothrombin time; aPTT, activated partial thromboplastin time; ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDH, lactate dehydrogenase; Hb, hemoglobin; –, negative; MAT; microscopic agglutination test; RT-PCR, reverse transcription PCR; DENV, dengue virus; CHIKV, chikungunya virus; YFV, yellow fever virus; ZIKV, Zika virus; +, positive.
†Blood samples were obtained 5 days after illness onset. These tests were performed at the National Reference Laboratory of the National Institute of Health, Bogotá, Colombia.

Main Article

Page created: April 14, 2016
Page updated: April 14, 2016
Page reviewed: April 14, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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