Volume 22, Number 6—June 2016
CME ACTIVITY - Synopsis
Infectious Disease Risk Associated with Contaminated Propofol Anesthesia, 1989–20141
Andrés Zorrilla-Vaca
, Jimmy J. Arevalo, Kevin Escandón-Vargas, Daniel Soltanifar, and Marek A. Mirski
, Jimmy J. Arevalo, Kevin Escandón-Vargas, Daniel Soltanifar, and Marek A. Mirski
Table 4
Summary of epidemiologic studies analyzing the association between infectious conditions and contaminated propofol anesthesia*
| Followed manufacturers’ precautions, study, year | Type of study | Preservative-free propofol† | Other agents compared with propofol | Type of infection | Hospital unit‡ | Association§ |
|---|---|---|---|---|---|---|
| Yes | ||||||
| Seeberger et al., 1998 | Retrospective cohort | Yes | Thiopentone | Sepsis | OR | No |
| Shimizu et al., 2010 | Cohort | ND | Sevoflurane | SSI | OR | Yes |
| Haddad et al., 2011 | Nested cohort | Yes | ND | Multiple¶ | ICU | Yes |
| Moehring et al., 2014 |
Case–control |
ND |
Fentanyl |
BSI |
ICU |
No |
| No | ||||||
| Bennett et al., 1995. (2) | Case–control and cohort | Yes | Sufentanil, alfentanil | BSI, SSI | OR | Yes |
| Henry et al., 2001 (4) | Case–control | Yes | ND | BSI, SSI | OR | Yes |
| McNeil et al., 1999 | Cohort | Yes | Sufentanil, fentanyl, midazolam, vecuronium | Fungemia, endophthalmitis | OR | Yes |
| Sebert et al., 2002. | Case–control | ND | ND | BSI | OR | No |
| Muller et al., 2010 (15) |
Retrospective cohort |
ND |
Fentanyl, midazolam |
BSI, SIRS |
OR |
Yes |
| ND | ||||||
| Kontopoulou et al., 2012 |
Case–control |
ND |
ND |
BSI |
ICU |
Yes |
| *Complete data and full references are available in the Technical Appendix; OR, operating room; ICU, intensive care unit; BSI, bloodstream infection; SSI, Surgical site infection; ND, not described in publication; SIRS, systemic inflammatory response syndrome. †Use of propofol without antimicrobial additives. ‡Hospital unit where the studies were conducted. §Conclusion of the analytical study regarding the association between propofol exposure and infectious events. ¶Multiple infection types, including ventilator-associated pneumonia, urosepsis, BSI, catheter-related infections, and others. | ||||||
1Part of this work was presented at the XXXI Colombian Congress of Anesthesiology and Critical Care, Cali, Columbia, July 2015.
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