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Volume 22, Number 8—August 2016

Phylogeographic Evidence for 2 Genetically Distinct Zoonotic Plasmodium knowlesi Parasites, Malaysia

Ruhani Yusof1, Md Atique Ahmed1, Jenarun Jelip, Hie Ung Ngian, Sahlawati Mustakim, Hani Mat Hussin, Mun Yik Fong, Rohela Mahmud, Frankie Anak Thomas Sitam, J. Rovie-Ryan Japning, Georges Snounou, Ananias A. Escalante, and Yee Ling LauComments to Author 
Author affiliations: University of Malaya Faculty of Medicine, Kuala Lumpur, Malaysia (R. Yusof, M.A. Ahmed, M.Y. Fong, R. Mahmud, Y.L. Lau); Sabah State Health Department, Sabah, Malaysia (J. Jelip); Hospital Kapit, Sarawak, Malaysia (H.U. Ngian); Hospital Tengku Microbiology Laboratory, Ampuan Rahimah, Selangor, Malaysia (S. Mustakim); Kelantan State Health Department, Kelantan, Malaysia (H.M. Hussin); Department of Wildlife and National Parks Peninsular Malaysia, Kuala Lumpur, Malaysia (F.A.T. Sitam, J. Rovie-Ryan); Sorbonne Universités, INSERM, Paris, France (G. Snounou); Temple University, Philadelphia, PA, USA (G. Snounou, A.A. Escalante)

Main Article

Table 3

Genetic characteristics of the 2 genetically distinct zoonotic Plasmodium knowlesi parasite populations in Malaysia*

Gene and location No. samples No. haplotypes No. polymorphic sites Haplotype diversity ±SD Nucleotide diversity ±SD Average. no. nucleotide differences
PkA-type 18S rRNA
Peninsular Malaysia 105 47 62 0.906 ±0.0.025 0. 0.00284 ±0.00024 2.66667
Malaysian Borneo 105 48 85 0.871 ±0.031 0.00276 ±0.0.00029 2.59341
0.941 ±0.0.011
0.00324 ±0.00019
Peninsular Malaysia 53 20 20 0.827 ±0.039 0.00141 ±0.00018 1.52685
Malaysian Borneo 84 25 25 0.676 ±0.057 0.00115 ±0.00014 1.24498
Overall 137 44 39 0.848 ±0.025 0.00215 ±0.00013 2.33104

*PkA-type 18S rRNA, P. knowlesi type A small subunit ribosomal 18S RNA; PkCOX1 P. knowlesi cytochrome oxidase subunit I.

Main Article

1These authors contributed equally to this article.

Page created: July 15, 2016
Page updated: July 15, 2016
Page reviewed: July 15, 2016
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