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Volume 22, Number 8—August 2016
Letter

Artemisinin-Resistant Plasmodium falciparum K13 Mutant Alleles, Thailand–Myanmar Border

Mikael Boullé1, Benoit Witkowski1, Valentine Duru, Kanlaya Sriprawat, Shalini K. Nair, Marina McDew-White, Tim J.C. Anderson, Aung Pyae Phyo, Didier Menard, and François Nosten
Author affiliations: Mahidol University Faculty of Tropical Medicine, Mae Sot, Thailand (M. BoulléSriprawat K, A.P. Phyo, F. Nosten); Institut Pasteur in Cambodia, Phnom Penh, Cambodia (B. Witkowski, V. Duru, D. Menard); Texas Biomedical Research Institute, San Antonio, Texas, USA (S.K. Nair, M. McDew-White; T.J.C. Anderson; F. Nosten); University of Oxford Nuffield Department of Medicine, Oxford, UK (F. Nosten)

Main Article

Figure

Distribution of parasite clearance half-lives (n = 33, squares) and Ring-stage survival assay survival rates (n = 25, circles) of Plasmodium falciparum isolates from patients on the Thailand–Myanmar border, determined on the basis of each K13 genotype. Mean survival rate of duplicate measures are showed for each isolate. Dashed line represents the cutoff value for parasite clearance half-life (artemisinin resistance >5 h) and RSA survival (artemisinin resistance >1%). K13 alleles N458Y and

Figure. Distribution of parasite clearance half-lives (n = 33, squares) and Ring-stage survival assay survival rates (n = 25, circles) of Plasmodium falciparum isolates from patients on the Thailand–Myanmar border, determined on the basis of each K13 genotype. Mean survival rate of duplicate measures are showed for each isolate. Dashed line represents the cutoff value for parasite clearance half-life (artemisinin resistance >5 h) and RSA survival (artemisinin resistance >1%). K13 alleles N458Y and C580Y were consistently associated with parasite clearance half-life and survival rates above threshold. Bold text indicates K13 alleles with variable parasite clearance half-life and RSA associations. Horizontal bars represent median values for each K13 genotype. Survival rate for laboratory reference 3D7 strain was 0.2%.

Main Article

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Main Article

1These authors contributed equally to this article.

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