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Volume 22, Number 8—August 2016
Research

Exposure-Specific and Age-Specific Attack Rates for Ebola Virus Disease in Ebola-Affected Households, Sierra Leone

Hilary Bower, Sembia Johnson, Mohamed S. Bangura, Alie Joshua Kamara, Osman Kamara, Saidu H. Mansaray, Daniel Sesay, Cecilia Turay, Francesco Checchi, and Judith R. GlynnComments to Author 
Author affiliations: London School of Hygiene & Tropical Medicine, London, UK (H. Bower, J.R. Glynn); Save the Children, Freetown, Sierra Leone (S. Johnson, M.S. Bangura, A.J. Kamara, O. Kamara, S.H. Mansaray, D. Sesay, C. Turay); Save the Children, London (F. Checchi)

Main Article

Table 5

Sensitivity analysis showing risk factors associated with development of EVD as a subsequent case-patient in Ebola-affected households, Kerry Town, Sierra Leone, 2014–2015*

Risk factor Total, excluding probable cases, N = 764
No. patients/no. total (%)† Adjusted RR‡ (95% CI) p value§
Sex
M 114/315 (36.2) 1.0 (0.83–1.2)
F
188/449 (41.9)
1
1.0
Age, y
<2 21/50 (42.0) 0.99 (0.66–1.5)
2–4 22/72 (30.6) 0.98 (0.68–1.4)
5–9 27/116 (23.3) 0.69 (0.47–1.0)
10–14 26/106 (24.5) 0.60 (0.39–0.93)
15–19 34/94 (36.2) 0.77 (0.52–1.1)
20–29 63/146 (43.2) 1
30–39 47/81 (58.0) 1.2 (0.86–1.6)
40–49 28/44 (63.6) 1.2 (0.82–1.8)
>50
33/53 (62.3)
1.5 (1.1–2.0)
0.002
Maximum exposure
Handled corpse 60/72 (83.3) 40.6 (8.5–194.5)
Handled fluids 65/112 (58.0) 30.5 (6.4–144.8)
Direct wet contact 125/276 (45.3) 24.1 (5.2–113.2)
Direct dry contact 41/119 (34.5) 16.7 (3.6–78.1)
Indirect wet contact 5/19 (26.3) 17.2 (3.1–94.7)
Indirect dry contact 4/70 (5.7) 2.3 (0.37–14.3)
Minimal/no contact
2/96 (2.1)
1
<0.001
Position in household
Household head 22/50 (44.0) 0.58 (0.35–0.98)
Household member
280/714 (39.2)
1
0.02
Household size
>16 108/197 (54.8) 2.6 (0.98–6.7)
11–15 90/282 (31.9) 1.5 (0.57–3.9)
6–10 96/245 (39.2) 2.3 (0.89–5.7)
1–5 8/40 (20.0) 1 0.04

*Subsequent case-patients were any household members who contracted EVD after the first (primary) case-patient. EVD, Ebola virus disease; RR, risk ratio.
†Excluded data: 4 deaths from uncertain cause; 27 persons with no individual-level data, 97 primary case-patients; 45 case-patients were classified as having EVD on the basis of their histories but had no diagnosis of EVD at the time. Missing data: 2 persons with age unknown.
‡Adjusted for clustering and all variables in the model.
§p values calculated from likelihood ratio test in logistic regression model.

Main Article

Page created: July 15, 2016
Page updated: July 15, 2016
Page reviewed: July 15, 2016
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