Volume 22, Number 8—August 2016
Dispatch
Asymptomatic Plasmodium Infections in Children in Low Malaria Transmission Setting, Southwestern Uganda1
Michelle E. Roh2, Caesar Oyet2, Patrick Orikiriza, Martina Wade, Gertrude N. Kiwanuka, Juliet Mwanga-Amumpaire, Sunil Parikh3
, and Yap Boum3
, and Yap Boum3
Table 2
Diagnostic performance of RDT and microscopy for Plasmodium infections in children in 3 districts, southwestern Uganda*
| Diagnostic accuracy of RDT† | Plasmodium infection | P. falciparum infection | Non–P. falciparum infection‡ |
|---|---|---|---|
| Sensitivity (95% CI) | 63.6 (40.7–82.8) | 75.0 (42.8–94.5) | 10.0 (0.3–44.5) |
| Specificity (95% CI) | 95.4 (93.4–96.9) | 95.1 (93.1–96.7) | 99.8 (99.1–100.0) |
| PPV (95% CI) | 33.3 (19.6–49.5) | 23.1 (11.1–39.3) | 50.0 (1.3–98.7) |
| NPV (95% CI) | 98.6 (97.3–99.4) | 99.5 (98.5–99.9) | 98.6 (97.3–99.3) |
| Agreement, % | 94.3 | 94.8 | 98.3 |
| κ |
0.41 |
0.33 |
0.15 |
| *NPV, negative predictive value; PPV, positive predictive value; RDT, rapid diagnostic test. †SD Bioline Malaria Ag Pf/Pan (P. falciparum or other Plasmodium species; Standard Diagnostics, Gyeonggi-do, South Korea). ‡Children with mixed infections were excluded from analysis. | |||
1Preliminary results from this study were presented at the 64th Annual Meeting of the American Society of Tropical Medicine and Hygiene, October 25–29, 2015, Philadelphia, Pennsylvania, USA.
2These first authors contributed equally to this article.
3These senior authors contributed equally to this article.
Page created: July 15, 2016
Page updated: July 15, 2016
Page reviewed: July 15, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.