TY - JOUR AU - Haaskjold, Yngvar Lunde AU - Bolkan, Håkon Angell AU - Krogh, Kurt Østhuus AU - Jongopi, James AU - Lundeby, Karen Marie AU - Mellesmo, Sindre AU - Garcés, Pedro San José AU - Jøsendal, Ola AU - Øpstad, Åsmund AU - Svensen, Erling AU - Fuentes, Luis Matias Zabala AU - Kamara, Alfred Sandy AU - Riera, Melchor AU - Arranz, Javier AU - Roberts, David AU - Stamper, Paul AU - Austin, Paula AU - Moosa, Alfredo AU - Marke, Dennis AU - Hassan, Shoaib AU - Eide, Geir Egil AU - Berg, Åse AU - Blomberg, Bjørn T1 - Clinical Features of and Risk Factors for Fatal Ebola Virus Disease, Moyamba District, Sierra Leone, December 2014–February 2015 T2 - Emerging Infectious Disease journal PY - 2016 VL - 22 IS - 9 SP - 1537 SN - 1080-6059 AB - The 2013–2016 outbreak of Ebola virus disease (EVD) in West Africa infected >28,000 people, including >11,000 who died, and disrupted social life in the region. We retrospectively studied clinical signs and symptoms and risk factors for fatal outcome among 31 Ebola virus–positive patients admitted to the Ebola Treatment Center in Moyamba District, Sierra Leone. We found a higher rate of bleeding manifestations than reported elsewhere during the outbreak. Significant predictors for death were shorter time from symptom onset to admission, male sex, high viral load on initial laboratory testing, severe pain, diarrhea, bloody feces, and development of other bleeding manifestations during hospitalization. These risk factors for death could be used to identify patients in need of more intensive medical support. The lack of fever in as many as one third of EVD cases may have implications for temperature-screening practices and case definitions. KW - Ebola hemorrhagic fever KW - Ebola virus disease KW - neglected diseases KW - Sierra Leone KW - viruses KW - fatal disease KW - risk factors KW - clinical features DO - 10.3201/eid2209.151621 UR - https://wwwnc.cdc.gov/eid/article/22/9/15-1621_article ER - End of Reference