TY - JOUR
AU - Baker, Kate
AU - Dallman, Timothy
AU - Behar, Adi
AU - Weill, François-Xavier
AU - Gouali, Malika
AU - Sobel, Jeremy
AU - Fookes, Maria
AU - Valinsky, Lea
AU - Gal-Mor, Ohad
AU - Connor, Thomas
AU - Nissan, Israel
AU - Bertrand, Sophie
AU - Parkhill, Julian
AU - Jenkins, Claire
AU - Cohen, Dani
AU - Thomson, Nicholas
T1 - Travel- and Community-Based Transmission of Multidrug-Resistant Shigella sonnei Lineage among International Orthodox Jewish Communities
T2 - Emerging Infectious Disease journal
PY - 2016
VL - 22
IS - 9
SP - 1545
SN - 1080-6059
AB - Shigellae are sensitive indicator species for studying trends in the international transmission of antimicrobial-resistant Enterobacteriaceae. Orthodox Jewish communities (OJCs) are a known risk group for shigellosis; Shigella sonnei is cyclically epidemic in OJCs in Israel, and sporadic outbreaks occur in OJCs elsewhere. We generated whole-genome sequences for 437 isolates of S. sonnei from OJCs and non-OJCs collected over 22 years in Europe (the United Kingdom, France, and Belgium), the United States, Canada, and Israel and analyzed these within a known global genomic context. Through phylogenetic and genomic analysis, we showed that strains from outbreaks in OJCs outside of Israel are distinct from strains in the general population and relate to a single multidrug-resistant sublineage of S. sonnei that prevails in Israel. Further Bayesian phylogenetic analysis showed that this strain emerged approximately 30 years ago, demonstrating the speed at which antimicrobial drug–resistant pathogens can spread widely through geographically dispersed, but internationally connected, communities.
KW - Shigella sonnei
KW - shigellosis
KW - Enterobacteriaceae
KW - bacteria
KW - diarrhea
KW - dysentery
KW - amebiasis
KW - gastroenteritis
KW - antimicrobial resistance
KW - Jewish orthodox
KW - Israel
KW - Europe
KW - United States
KW - Canada
KW - enteric infections
KW - France
KW - Belgium
DO - 10.3201/eid2209.151953
UR - https://wwwnc.cdc.gov/eid/article/22/9/15-1953_article
ER - End of Reference