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Volume 22, Number 9—September 2016
Dispatch

Multidrug-Resistant Shigella Infections in Patients with Diarrhea, Cambodia, 2014–2015

Kamonporn Poramathikul, Ladaporn BodhidattaComments to Author , Sivhour Chiek, Wilawan Oransathid, Sirigade Ruekit, Panida Nobthai, Woradee Lurchachaiwong, Oralak Serichantalergs, Chanthap Lon, and Brett Swierczewski
Author affiliations: Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand (K. Poramathikul, L. Bodhidatta, W. Oransathid, S. Ruekit, P. Nobthai, W. Lurchachaiwong, O. Serichantalergs, B. Swierczewski); Battambang Provincial Referral Hospital, Battambang, Cambodia (S. Chiek); Armed Forces Research Institute of Medical Sciences, Phnom Penh, Cambodia (C. Lon)

Main Article

Table 2

Antimicrobial susceptibility results and molecular characterization of resistance genes of Shigella isolates collected from patients in Cambodia, July 2014–April 2015*

Isolate no. Organism Antimicrobial resistance CIP MIC, µg/mL† Amino acid substitutions in QRDR
 AZM MIC,
µg/mL‡ mphA gene ESBL confirmatory test β-lactamase genes
gyrA
 parC
Ser 83 Asp 87 Ser 57 Ser 80
1 S. flexneri 2a AMP-SXT-TET-NAL 0.25 Leu – – – 2.00 Neg Neg TEM-1, OXA-1
2 S. flexneri 2a AMP-SXT-TET-NAL 0.25 Leu – – – 1.50 Neg Neg TEM-1, OXA-1
3 S. flexneri 2v AMP-SXT-TET-NAL 0.19 Leu – – – 1.50 Neg Neg TEM-1, OXA-1
4 S. flexneri 3a AMP-SXT-TET-NAL 0.25 Leu – – – 1.00 Neg Neg TEM-1
5 S. flexneri 3a AMP-SXT-TET-NAL 0.19 Leu – – – 1.50 Neg Neg TEM-1
6 S. flexneri 3a AMP-SXT-TET-NAL-CIP 4.00 Leu – Arg – 0.75 Neg Neg TEM-1
7 S. flexneri 3a AMP-SXT-TET-NAL-CIP 4.00 Leu – Arg – 1.00 Neg Neg TEM-1
8 S. flexneri 3a AMP-SXT-TET-NAL-CIP 4.00 Leu – Arg – 1.00 Neg Neg TEM-1
9 S. flexneri 3a AMP-SXT-TET-NAL-CIP-AZM-CRO-CTX 6.00 Leu – Arg – 32.00 Pos Pos TEM-1, CTX-M-27
10 S. sonnei AMP-SXT-TET-NAL-CIP-CRO-CTX-CAZ 6.00 Leu Gly – Ile 4.00 Neg Pos CTX-M-55

*AMP, ampicillin; Arg, arginine; Asp, aspartate; AZM, azithromycin; CAZ, ceftazidime; CIP; ciprofloxacin; CRO, ceftriaxone; CTX, cefotaxime; ESBL, extended-spectrum β-lactamase; Gly, glycine; Ile, isoleucine; Leu, leucine; NAL, nalidixic acid; Neg, negative; Pos, positive; QRDR, quinolone-resistance determining region; Ser, serine; SXT, trimethoprim/sulfamethoxazole; TET, tetracycline; –, no amino acid substitutions found.
†CIP MIC interpretive criteria for Enterobacteriaceae is susceptible <1, resistant >4 µg/mL.
‡AZM MIC interpretive criteria for Salmonella enterica serovar Typhi is susceptible <16, resistant >32 µg/mL.

Main Article

Page created: August 16, 2016
Page updated: August 16, 2016
Page reviewed: August 16, 2016
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