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Volume 22, Number 9—September 2016
Dispatch

Mutation in West Nile Virus Structural Protein prM during Human Infection

Yaniv LustigComments to Author , Robert Lanciotti, Musa Hindiyeh, Nathan Keller, Ron Milo, Shlomo Mayan, and Ella Mendelson
Author affiliations: Sheba Medical Center, Tel-Hashomer, Israel (Y. Lustig, M. Hindiyeh, N. Keller, E. Mendelson); Centers for Disease Control and Prevention, Fort Collins, Colorado, USA (R.S. Lanciotti); School of Public Health, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel (M. Hindiyeh, E. Mendelson); Faculty of Health Sciences, Ben-Gurion University of the Negev, Be'er sheva, Israel (R. Milo); Barzilai Medical Center, Ashkelon, Israel (R. Milo, S. Mayan)

Main Article

Table

Serologic and molecular results in serum and urine samples from a patient with persistent WNV infection. Israel, 2014

Days after infection†
 Days after illness onset‡
 Serum, copies/mL
 Urine, copies/mL
 Serum IgM (ELISA result)§
 Serum IgG (ELISA result)§
 Serum neutralization titers‡
 Amino acid in prM 20 (%)
14 7 6 × 10¶ Pos 1.8 Neg Neg T(100)
19 12 8.8 × 107 ND ND ND T (100)
22 15 2.5 × 104 2.3 × 106 Pos 8.07 Int 1.35 1:20 T (100)
23 16 3.6 × 103 2 × 106 Pos 8.16 Int 1.35 1:20
24 17 8.3 × 103 4.1 × 106 Pos 8.12 Pos 1.65 ND
25 18 1.2 × 104 2 × 106 Pos 8.29 Pos 1.98 1:20
26 19 1.8 × 104 1.8 × 106 Pos 8.04 Pos 1.95 ND T (100)
35 28 1 × 104 1.3 × 105 Pos 8.30 Pos 2.91 1:40 I (80), T (20)
50 43 6 × 102 8.5 × 103 Pos 8.20 Pos 3.27 1:40
54 47 2 × 103 6 × 102 Pos 8.15 Pos 3.43 1:40
61 54 Neg 1.1 × 104 Pos 7.94 Pos 3.49 1:40
68 61 Neg 6.8 × 101 Pos 7.42 Pos 3.54 1:40
76 69 Neg Neg Pos 7.35 Pos 3.61 1:40

*I, isoleucine; Int, intermediate; ND, not done; Neg, negative; Pos, positive; T, threonine.
†Based on patient’s memory of being bitten by a mosquito.
‡Days after start of headache, abdominal pain, nausea, and fever.
§Results of ELISA IgM and IgG given in relative units.
¶Sample sequenced.

Main Article

Page created: August 16, 2016
Page updated: August 16, 2016
Page reviewed: August 16, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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