TY - JOUR AU - Soysal, Nurcan AU - Mariani-Kurkdjian, Patricia AU - Smail, Yasmine AU - Liguori, Sandrine AU - Gouali, Malika AU - Loukiadis, Estelle AU - Fach, Patrick AU - Bruyand, Mathias AU - Blanco, Jorge AU - Bidet, Philippe AU - Bonacorsi, Stéphane T1 - Enterohemorrhagic Escherichia coli Hybrid Pathotype O80:H2 as a New Therapeutic Challenge T2 - Emerging Infectious Disease journal PY - 2016 VL - 22 IS - 9 SP - 1604 SN - 1080-6059 AB - We describe the epidemiology, clinical features, and molecular characterization of enterohemorrhagic Escherichia coli (EHEC) infections caused by the singular hybrid pathotype O80:H2, and we examine the influence of antibiotics on Shiga toxin production. In France, during 2005–2014, a total of 54 patients were infected with EHEC O80:H2; 91% had hemolytic uremic syndrome. Two patients had invasive infections, and 2 died. All strains carried stx2 (variants stx2a, 2c, or 2d); the rare intimin gene (eae-ξ); and at least 4 genes characteristic of pS88, a plasmid associated with extraintestinal virulence. Similar strains were found in Spain. All isolates belonged to the same clonal group. At subinhibitory concentrations, azithromycin decreased Shiga toxin production significantly, ciprofloxacin increased it substantially, and ceftriaxone had no major effect. Antibiotic combinations that included azithromycin also were tested. EHEC O80:H2, which can induce hemolytic uremic syndrome complicated by bacteremia, is emerging in France. However, azithromycin might effectively combat these infections. KW - enterohemorrhagic Escherichia coli KW - Shiga toxin KW - hemolytic uremic syndrome KW - extraintestinal virulence factors KW - pS88 plasmid KW - bacteremia KW - antibiotic resistance KW - antibiotic treatment KW - emergence KW - E. coli KW - O80:42 KW - HUS KW - bacteria KW - antimicrobial resistance KW - antimicrobial KW - enteric infections DO - 10.3201/eid2209.160304 UR - https://wwwnc.cdc.gov/eid/article/22/9/16-0304_article ER - End of Reference