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Volume 23, Number 10—October 2017
Research Letter

Six-Month Response to Delamanid Treatment in MDR TB Patients

Cathy HewisonComments to Author , Gabriella Ferlazzo, Zaza Avaliani, Armen Hayrapetyan, Sylvie Jonckheere, Zarema Khaidarkhanova, Erika Mohr, Animesh Sinha, Alena Skrahina, Debrah Vambe, Irina Vasilyeva, Nathalie Lachenal, and Francis Varaine
Author affiliations: Médecins Sans Frontières, Paris, France (C. Hewison, F. Varaine); Médecins Sans Frontières, Cape Town, South Africa (G. Ferlazzo, E. Mohr); National Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia (Z. Avaliani); National Tuberculosis Control Centre Ministry of Health, Yerevan, Armenia (A. Hayrapetyan); Médecins Sans Frontières, Johannesburg, South Africa (S. Jonckheere); Republican Tuberculosis Dispensary, Grozny, Chechnya, Russian Federation (Z. Khaidarkhanova); Médecins Sans Frontières, Minsk, Belarus (A. Sinha); Republican Research and Practical Centre for Pulmonology and Tuberculosis, Minsk (A. Skrahina); Swaziland National Tuberculosis Control Program, Mbabane, Swaziland (D. Vambe); Research Institute of Phthisiopulmonology of I.M. Sechenov First MSMU, Moscow, Russian Federation (I. Vasilyeva); Médecins Sans Frontières, Geneva, Switzerland (N. Lachenal)

Main Article


Demographic, clinical, and bacteriological characteristics at baseline of 53 patients starting a delamanid-containing MDR TB treatment regimen*

No. (%) patients or median (IQR)
   M 36 (67.9)
17 (32.1)
Age at delamanid start, y 29.5 (20.0–43.0)
11 (20.8)
HIV co-infected, n = 48 8 (16.7)
HCV co-infected, n = 42 8 (19.0)
Malnutrition,† n = 51 21 (41.2)
Serum albumin at delamanid start, g/L, n = 46
37.6 (32.0–37.6)
WHO case definition
   New case 4 (7.5)
   Relapse 5 (9.4)
   Treatment after being lost to follow-up 5 (9.4)
   Treatment after failure 32 (60.4)
7 (13.5)
Previously treated 49 (92.4)
   With first-line drugs only 1 (2.1)
   With second-line drugs 48 (97.9)
   MDR TB confirmed
51 (96.2)
Drug resistance subgroups among confirmed MDR TB
   MDR TB only‡ 10 (19.6)
   Pre–XDR TB FQ 6 (11.8)
   Pre–XDR TB Inj 8 (15.7)
27 (52.9)
Radiograph features
   Bilateral, n = 45 35 (77.8)
   Cavities, n = 43 26 (60.5)
   Bilateral or cavity, n = 45
40 (88.9)
Culture positive at delamanid start
37 (69.8)
*HCV, hepatitis C virus serology; HIV, human immunodeficiency virus; MDR TB, multidrug-resistant tuberculosis; pre–XDR TB FQ, MDR TB with fluoroquinolone resistance; pre–XDR TB Inj, MDR TB with resistance to injectable drugs; WHO, World Health Organization; XDR TB, extensively drug-resistant tuberculosis. 
†Malnutrition: either BMI <18.5 kg2/cm, mid-upper arm circumference 
<16cm, or weight <50 kg in 3 patients from South Africa without height measurement. 
‡Without resistance to fluoroquinolone or injectable drugs.

Main Article

Page created: September 19, 2017
Page updated: September 19, 2017
Page reviewed: September 19, 2017
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