TY - JOUR AU - Maryandyshev, Andrey AU - Pontali, Emanuele AU - Tiberi, Simon AU - Akkerman, Onno AU - Ganatra, Shashank AU - Sadutshang, Tsetan Dorji AU - Alffenaar, Jan-Willem AU - Amale, Rohit AU - Mullerpattan, Jai AU - Topgyal, Sonam AU - Udwadia, Zarir Farokh AU - Centis, Rosella AU - D’Ambrosio, Lia AU - Sotgiu, Giovanni AU - Migliori, Giovanni Battista T1 - Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis T2 - Emerging Infectious Disease journal PY - 2017 VL - 23 IS - 10 SP - 1718 SN - 1080-6059 AB - We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options. KW - MDR-TB KW - XDR-TB KW - bedaquiline KW - delamanid KW - combination treatment KW - effectiveness KW - safety KW - tolerability KW - Europe KW - India KW - Russia KW - Italy KW - United Kingdom KW - Switzerland KW - pulmonary KW - MDR TB KW - XDR TB KW - the Netherlands KW - bacteria KW - Mycobacterium tuberculosis KW - multidrug-resistant tuberculosis KW - tuberculosis KW - mycobacteria KW - antimicrobial resistance KW - respiratory infections KW - multidrug resistance KW - TB DO - 10.3201/eid2310.170834 UR - https://wwwnc.cdc.gov/eid/article/23/10/17-0834_article ER - End of Reference