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Volume 23, Number 11—November 2017
Research

Legionnaires’ Disease Outbreak Caused by Endemic Strain of Legionella pneumophila, New York, New York, USA, 2015

Pascal LapierreComments to Author , Elizabeth Nazarian, Yan Zhu, Danielle Wroblewski, Amy Saylors, Teresa Passaretti, Scott Hughes, Anthony Tran, Ying Lin, John Kornblum, Shatavia S. Morrison, Jeffrey W. Mercante, Robert Fitzhenry, Don Weiss, Brian H. Raphael, Jay K. Varma, Howard A. Zucker, Jennifer L. Rakeman, and Kimberlee A. Musser
Author affiliations: Wadsworth Center, Albany, New York, USA (P. Lapierre, E. Nazarian, Y. Zhu, D. Wroblewski, A. Saylors, T. Passaretti, H.A. Zucker, K.A. Musser); New York City Department of Health and Mental Hygiene, New York, New York, USA (S. Hughes, A. Tran, Y. Lin, J. Kornblum, R. Fitzhenry, D. Weiss, J.K. Varma, J.L. Rakeman); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (S.S. Morrison, J.W. Mercante, B.H. Raphael); New York State Health Commissioner, Albany (H.A. Zucker)

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Figure 4

Blast ring genome comparison of Legionella pneumophila strains from investigation of Legionnaires’ disease outbreak caused by an endemic strain of L. pneumophila, New York City, New York, USA, 2015. Comparison is shown between South Bronx outbreak strain (F4469) and other sequenced strains (Philadelphia 1, Corby, Alcoy, Paris, and Lens). The 2 innermost circles indicate G + C content and G + C skew, respectively, of the outbreak strain genome. Gaps in outer circles indicate genome areas in strai

Figure 4. Blast ring genome comparison of Legionella pneumophila strains from investigation of Legionnaires’ disease outbreak caused by an endemic strain of L. pneumophila, New York City, New York, USA, 2015. Comparison is shown between South Bronx outbreak strain (F4469) and other sequenced strains (Philadelphia 1, Corby, Alcoy, Paris, and Lens). The 2 innermost circles indicate G + C content and G + C skew, respectively, of the outbreak strain genome. Gaps in outer circles indicate genome areas in strain F4469 that are either absent or of low identity in compared genomes. Most of these regions are composed of virulence factor–associated genes, such as an F-type IVA secretion system, effector protein genes, toxin/antitoxin loci, and genes with unknown functions. Hip, hippurate hydrolysis gene; Lub, Legionella U-box gene; RTX, repeats in structural toxin gene; Sid; substrate of macrophage killing/defective organelle trafficking transporter gene.

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Page created: October 16, 2017
Page updated: October 16, 2017
Page reviewed: October 16, 2017
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