Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 23, Number 12—December 2017
Dispatch

Outbreak of Yellow Fever among Nonhuman Primates, Espirito Santo, Brazil, 2017

Natália Coelho Couto de Azevedo FernandesComments to Author , Mariana Sequetin Cunha, Juliana Mariotti Guerra, Rodrigo Albergaria Réssio, Cinthya dos Santos Cirqueira, Silvia D’Andretta Iglezias, Júlia de Carvalho, Emerson L.L. Araujo, José Luiz Catão-Dias, and Josué Díaz-Delgado
Author affiliations: Instituto Adolfo Lutz, São Paulo, Brazil (N.C.C.A. Fernandes, M.S. Cunha, J.M. Guerra, R.A. Réssio, C.S. Cirqueira, S. D’Andretta Iglezias, J. de Carvalho, J. Díaz-Delgado); Ministério da Saúde, Brasília, Brazil (E.L.L. Araujo); Universidade de São Paulo, São Paulo (J.L. Catão-Dias, J. Díaz-Delgado)

Main Article

Figure 2

Histopathologic and immunohistochemical findings in the livers of neotropical nonhuman primates that died of yellow fever, Espirito Santo, Brazil, January 2017. Asterisks (*) indicate centrilobular veins. A) Midzonal and centrilobular bridging hepatocellular lytic necrosis. Original magnification ×40; hematoxylin and eosin (H&E) staining. Inset shows lytic hepatocellular necrosis with multiple Councilman-Rocha Lima (apoptotic) bodies (arrows). Original magnification ×400; H&E staining. B

Figure 2. Histopathologic and immunohistochemical findings in the livers of neotropical nonhuman primates that died of yellow fever, Espirito Santo, Brazil, January 2017. Asterisks (*) indicate centrilobular veins. A) Midzonal and centrilobular bridging hepatocellular lytic necrosis. Original magnification ×40; hematoxylin and eosin (H&E) staining. Inset shows lytic hepatocellular necrosis with multiple Councilman-Rocha Lima (apoptotic) bodies (arrows). Original magnification ×400; H&E staining. B) Massive (diffuse) hepatocellular lytic necrosis with severe centrilobular and midzonal hemorrhage. Original magnification ×40; H&E staining. Inset shows prominent hepatocellular necrosis and dropout, and erythrocytes replace the hepatic cords (there is some artifactual formalin pigment [acid hematin] in necrotic hepatocytes). Original magnification ×400; H&E staining. C) Massive macrovacuolar steatosis. Inset shows massive macrovacuolar steatosis mingled with single-cell hepatocellular necrosis (arrow). Original magnification ×400; H&E staining. D) Positive immunolabeling confined to remaining periportal hepatocytes and terminal plate. Original magnification ×40; immunohistochemical staining for yellow fever virus. Inset shows positive granular, cytoplasmic immunolabeling for yellow fever virus antigen in periportal hepatocytes and terminal plate. Original magnification ×400; immunohistochemical staining for yellow fever virus.

Main Article

Page created: November 16, 2017
Page updated: November 16, 2017
Page reviewed: November 16, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external