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Volume 23, Number 12—December 2017
Research Letter

Angiostrongylus cantonensis DNA in Cerebrospinal Fluid of Persons with Eosinophilic Meningitis, Laos

Damien K.Y. MingComments to Author , Sayaphet Rattanavong, Tehmina Bharucha, Onanong Sengvilaipaseuth, Audrey Dubot-Pérès, Paul N. Newton, and Matthew T. Robinson
Author affiliations: Imperial College London, London, UK (D.K.Y. Ming); Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit, Vientiane, Laos (D.K.Y. Ming, S. Rattanavong, T. Bharucha, O. Sengvilaipaseuth, A. Dubot-Pérès, P.N. Newton, M.T. Robinson); University College London, London (T. Bharucha); Aix-Marseille Université, Marseille, France (A. Dubot-Pérès); University of Oxford, Oxford, UK (P.N. Newton, M.T. Robinson)

Main Article

Table

Demographics and clinical characteristics of 35 patients with eosinophilic meningitis tested by qPCR for Angiostrongylus cantonensis parasites*

Characteristic Positive, n = 4† Negative, n = 31†
Median age, y (IQR)
 25 (21–42)
 25 (20–40)
Sex, no. (%)
M 4/4 (100) 19/31 (61)
F
 0
 12/31 (39)
Median duration of illness, d (IQR) 4 (1–9) 4 (0–6.5)
Median eosinophil % of total leukocyte count (IQR)
 65 (50–73)
 33 (14–56)
Diet in past mo
Raw fish 3/3 7/13
Raw shellfish 2/2 3/11
Raw snails 2/3 5/12
Raw crab
2/2
 2/11
Fulfilled WHO criteria for meningitis at admission, no. (%) 3/4 (75) 9/28 (32)
Median CSF opening pressure, cm H2O (IQR) 28 (22–35) 27 (17–40)
Median CSF leukocyte count, × 106 cells/L (IQR) 583 (493–1,198) 125 (40–580)
Median CSF protein, g/L (IQR) 0.68 (0.31–1.08) 0.56 (0.31–1.00)
Median CSF glucose, mmol/L (IQR) 2.7 (2.4–4.2) 3.1 (2.4–4.9)

*CSF, cerebrospinal fluid; IQR, interquartile range; qPCR, quantitative PCR; WHO, World Health Organization.
†Denominators vary according to available data.

Main Article

Page created: November 16, 2017
Page updated: November 16, 2017
Page reviewed: November 16, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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