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Volume 23, Number 2—February 2017
Research

Spread and Evolution of Respiratory Syncytial Virus A Genotype ON1, Coastal Kenya, 2010–2015

James R. OtienoComments to Author , Everlyn M. Kamau, Charles N. Agoti, Clement Lewa, Grieven Otieno, Ann Bett, Mwanajuma Ngama, Patricia A. Cane, and D. James Nokes
Author affiliations: Kenya Medical Research Institute (KEMRI)–Wellcome Trust Research Programme, Kilifi, Kenya (J.R. Otieno, E.M. Kamau, C.N. Agoti, C. Lewa, G. Otieno, A. Bett, M. Ngama, D.J. Nokes); Pwani University, Kilifi (C.N. Agoti); Public Health England, Salisbury, UK (P.A. Cane); University of Warwick, Coventry, UK (D.J. Nokes)

Main Article

Figure 3

Amino acid substitutions in respiratory syncytial virus A (RSV-A) G protein for sequences isolated in Kilifi Kenya from season 2011/2012 to 2014/2015. All unique protein sequences per epidemic were collated, aligned and the amino acid differences from the earliest sequence determined and marked with vertical colored bars, with the substituted amino acid residue color coded as shown by the key between panels A and B. A) Full aligned aa sequence inferred from the G gene sequences (ON1 and GA2); B)

Figure 3. Amino acid substitutions in respiratory syncytial virus A (RSV-A) G protein for sequences isolated in Kilifi Kenya from season 2011/2012 to 2014/2015. All unique protein sequences per epidemic were collated, aligned and the amino acid differences from the earliest sequence determined and marked with vertical colored bars, with the substituted amino acid residue color coded as shown by the key between panels A and B. A) Full aligned aa sequence inferred from the G gene sequences (ON1 and GA2); B) (ON1 only) focuses on the region of the ON1 duplication. The positions shown at the bottom of panels A and B are relative to the first amino acid of the regions analyzed, i.e., from amino acid positions 94 and 260, respectively, of the reference strain A2 (Ref: M74568). Indicated at the top of these panels are the functional domains of the G protein (panel A) and the 72-nt duplication of genotype ON1 (panel B; duplicated sequence I in “orange” and duplicated sequence II in “purple”). Below this, the histogram indicates the total number of changes at each position. C) Concurrent aa positions within the duplicated sequences I and II, and the respective aa substitutions (numbering similar to positions in panel B).

Main Article

Page created: January 17, 2017
Page updated: January 17, 2017
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