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Volume 23, Number 3—March 2017
Research Letter

Imported Leptospira licerasiae Infection in Traveler Returning to Japan from Brazil

Motoyuki Tsuboi, Nobuo Koizumi, Kayoko HayakawaComments to Author , Shuzo Kanagawa, Norio Ohmagari, and Yasuyuki Kato
Author affiliations: National Center for Global Health and Medicine, Tokyo, Japan (M. Tsuboi, K. Hayakawa, S. Kanagawa, N. Ohmagari, Y. Kato); National Institute of Infectious Diseases, Tokyo (N. Koizumi)

Main Article


Case descriptions of patients infected with Leptospira licerasiae in South America*

Patient no. Age, y/sex Location Occupation Symptoms Therapy Prognosis Ref.
VAR10 31/F Varillal, Peru Food vendor 2-d history of fever, malaise, chills, headache, dizziness Antipyretics Resolved 5 d later (7)
HAI029 19/F Iquitos, Peru Student/ domestic worker 5-d history of fever, malaise, chills, headache, dizziness, leg pain and weakness, abdominal pain, anorexia, nausea, vomiting None Resolved† (7)
NIID18 40/M Corumbá, Brazil Camera crew 1-d history of fever, shaking chills, retroorbital pain, arthralgia and myalgia in elbow and knee joints, burning skin pain over the whole body, congested bulbar conjunctivae CTRX 2 g/d for 4 d, then DOX 100 mg 2×/d for 3 d Resolved within 3 d after initiation of CTRX This study

*CTRX, ceftriaxone; DOX, doxycycline; ref., reference.
†The day when the symptoms resolved was not described in the report.

Main Article

  1. Chiriboga  J, Barragan  V, Arroyo  G, Sosa  A, Birdsell  DN, España  K, et al. High prevalence of intermediate Leptospira spp. DNA in febrile humans from urban and rural Ecuador. Emerg Infect Dis. 2015;21:21417.
  2. Koizumi  N, Muto  MM, Akachi  S, Okano  S, Yamamoto  S, Horikawa  K, et al. Molecular and serological investigation of Leptospira and leptospirosis in dogs in Japan. J Med Microbiol. 2013;62:6306.
  3. Koizumi  N, Muto  M, Yamamoto  S, Baba  Y, Kudo  M, Tamae  Y, et al. Investigation of reservoir animals of Leptospira in the northern part of Miyazaki Prefecture. Jpn J Infect Dis. 2008;61:4658.
  4. Azali  MA, Yean Yean  C, Harun  A, Aminuddin Baki  NN, Ismail  N. Molecular characterization of Leptospira spp. in environmental samples from North-Eastern Malaysia revealed a pathogenic strain, Leptospira alstonii. J Trop Med. 2016;2016:2060241.
  5. Saito  M, Villanueva  SY, Chakraborty  A, Miyahara  S, Segawa  T, Asoh  T, et al. Comparative analysis of Leptospira strains isolated from environmental soil and water in the Philippines and Japan. Appl Environ Microbiol. 2013;79:6019.
  6. Thaipadungpanit  J, Wuthiekanun  V, Chantratita  N, Yimsamran  S, Amornchai  P, Boonsilp  S, et al. Leptospira species in floodwater during the 2011 floods in the Bangkok Metropolitan Region, Thailand. Am J Trop Med Hyg. 2013;89:7946.
  7. Matthias  MA, Ricaldi  JN, Cespedes  M, Diaz  MM, Galloway  RL, Saito  M, et al. Human leptospirosis caused by a new, antigenically unique Leptospira associated with a Rattus species reservoir in the Peruvian Amazon. PLoS Negl Trop Dis. 2008;2:e213.
  8. Slack  AT, Kalambaheti  T, Symonds  ML, Dohnt  MF, Galloway  RL, Steigerwalt  AG, et al. Leptospira wolffii sp. nov., isolated from a human with suspected leptospirosis in Thailand. Int J Syst Evol Microbiol. 2008;58:23058.
  9. Levett  PN, Morey  RE, Galloway  RL, Steigerwalt  AG. Leptospira broomii sp. nov., isolated from humans with leptospirosis. Int J Syst Evol Microbiol. 2006;56:6713.
  10. Schmid  GP, Steere  AC, Kornblatt  AN, Kaufmann  AF, Moss  CW, Johnson  RC, et al. Newly recognized Leptospira species (“Leptospira inadai” serovar lyme) isolated from human skin. J Clin Microbiol. 1986;24:4846.

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