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Volume 23, Number 3—March 2017
Research

Comparison of Sputum-Culture Conversion for Mycobacterium bovis and M. tuberculosis

Colleen ScottComments to Author , Joseph S. Cavanaugh, Benjamin J. Silk, Julia Ershova, Gerald H. Mazurek, Philip A. LoBue, and Patrick K. Moonan
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Main Article

Table 1

Characteristics of patients with pulmonary tuberculosis caused by Mycobacterium bovis or Mycobacterium tuberculosis, United States, 2006–2013*

Variable Cause of tuberculosis
p value†
M. bovis, n = 297 M. tuberculosis, n = 30,848
Age, y
0–4 0 18 (0.1) 0.52
5–14 2 (0.7) 202 (0.7)
15–24 46 (15.5) 3966 (12.9)
25–44 105 (35.4) 10,553 (34.2)
45–64 99 (33.3) 10,237 (33.2)
>65 45 (15.2) 5872 (19.0)
Median age, y (interquartile range) 43 (29–56) 46 (30–60) 0.12
Sex
M 174 (58.6) 20,303 (65.8) 0.01
F 123 (41.4) 10,536 (34.2)
Race/ethnicity
White, non-Hispanic 9 (3.0) 5205 (16.8) <0.0001
Native American, non-Hispanic 0 456 (1.5)
Asian, non-Hispanic 3 (1.0) 7869 (26.0)
Black, non-Hispanic 8 (2.7) 7578 (25.0)
Hispanic 276 (93.2) 9177 (30.3)
Country of birth
United States 41 (13.8) 12,442 (40.3) <0.0001
Other‡ 256 (86.2) 18,371 (59.5)
Reported HIV status§
Positive 17 (5.7) 1851 (6.0) <0.0001
Negative 166 (55.9) 21,585 (70.0)
Unknown 114 (38.4) 7412 (24.0)
Clinical presentation at diagnosis
Pulmonary disease 193 (65.0) 27,757 (90.0) <0.0001
Pulmonary and extrapulmonary disease 104 (35.0) 3090 (10.0)
Computed tomography or other chest imaging findings¶
Cavitary disease 90/193 (46.6) 12,476/27,757 (45.0) 0.64
Noncavitary disease 103/193 (53.4) 15,281/27,757 (55.0)
Sputum smear result
Positive 189 (63.6) 20,744 (67.3) 0.40
Negative 98 (33.0) 9403 (30.5)
Not obtained 10 (3.4) 689 (2.2)
Bacillary burden#
High 84 (28.3) 11,154 (36.2) 0.03
Medium 120 (40.4) 11,445 (37.1)
Low 85 (28.6) 7734 (25.1)
Unknown 8 (2.7) 515 (1.7)
Treatment outcome**
Completed 235 (83.9) 25,535 (90.5) 0.001
Died 25 (8.9) 1447 (5.1)
Other†† 20 (7.4) 1238 (4.4)

*Values are no. (%) unless otherwise indicated. Sums of counts across categories for a specific factor might be less than total counts in the column headings because of missing or incomplete data.
†Determined by using Pearson χ2 test unless otherwise indicated.
‡Restricted to foreign-born persons.
§HIV status data are unknown for patients reported for California and Vermont during 2006–2011. Unknown also includes data from other states reporting unknown HIV status for tuberculosis patients.
¶Cavitary status was documented if reports of either conventional radiography or computed tomography indicated its presence.
#A bacillary burden composite variable was created by using smear status and radiographic evidence of cavitation.
**Outcome data are available for, and restricted to, patients reported during 2006–2013.
††Includes treatment stopped because of adverse events; patients were lost to follow-up, moved, refused treatment; and unknown reasons.

Main Article

Page created: February 17, 2017
Page updated: February 17, 2017
Page reviewed: February 17, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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