TY - JOUR AU - Scott, Colleen AU - Cavanaugh, Joseph AU - Silk, Benjamin AU - Ershova, Julia AU - Mazurek, Gerald AU - LoBue, Philip AU - Moonan, Patrick T1 - Comparison of Sputum-Culture Conversion for Mycobacterium bovis and M. tuberculosis T2 - Emerging Infectious Disease journal PY - 2017 VL - 23 IS - 3 SP - 456 SN - 1080-6059 AB - Current US guidelines recommend longer treatment for tuberculosis (TB) caused by pyrazinamide-resistant organisms (e.g., Mycobacterium bovis) than for M. tuberculosis TB. We compared treatment response times for patients with M. bovis TB and M. tuberculosis TB reported in the United States during 2006–2013. We included culture-positive, pulmonary TB patients with genotyping results who received standard 4-drug treatment at the time of diagnosis. Time to sputum-culture conversion was defined as time between treatment start date and date of first consistently culture-negative sputum. We analyzed 297 case-patients with M. bovis TB and 30,848 case-patients with M. tuberculosis TB. After 2 months of treatment, 71% of M. bovis and 65% of M. tuberculosis TB patients showed conversion of sputum cultures to negative. Likelihood of culture conversion was higher for M. bovis than for M. tuberculosis, even after controlling for treatment administration type, sex, and a composite indicator of bacillary burden. KW - Mycobacterium bovis KW - Mycobacterium tuberculosis KW - bacteria KW - tuberculosis and other mycobacteria KW - tuberculosis KW - disease KW - sputum KW - culture conversion KW - sputum-culture conversion KW - United States DO - 10.3201/eid2303.161916 UR - https://wwwnc.cdc.gov/eid/article/23/3/16-1916_article ER - End of Reference