TY - JOUR
AU - Scott, Colleen
AU - Cavanaugh, Joseph
AU - Silk, Benjamin
AU - Ershova, Julia
AU - Mazurek, Gerald
AU - LoBue, Philip
AU - Moonan, Patrick
T1 - Comparison of Sputum-Culture Conversion for Mycobacterium bovis and M. tuberculosis
T2 - Emerging Infectious Disease journal
PY - 2017
VL - 23
IS - 3
SP - 456
SN - 1080-6059
AB - Current US guidelines recommend longer treatment for tuberculosis (TB) caused by pyrazinamide-resistant organisms (e.g., Mycobacterium bovis) than for M. tuberculosis TB. We compared treatment response times for patients with M. bovis TB and M. tuberculosis TB reported in the United States during 2006–2013. We included culture-positive, pulmonary TB patients with genotyping results who received standard 4-drug treatment at the time of diagnosis. Time to sputum-culture conversion was defined as time between treatment start date and date of first consistently culture-negative sputum. We analyzed 297 case-patients with M. bovis TB and 30,848 case-patients with M. tuberculosis TB. After 2 months of treatment, 71% of M. bovis and 65% of M. tuberculosis TB patients showed conversion of sputum cultures to negative. Likelihood of culture conversion was higher for M. bovis than for M. tuberculosis, even after controlling for treatment administration type, sex, and a composite indicator of bacillary burden.
KW - Mycobacterium bovis
KW - Mycobacterium tuberculosis
KW - bacteria
KW - tuberculosis and other mycobacteria
KW - tuberculosis
KW - disease
KW - sputum
KW - culture conversion
KW - sputum-culture conversion
KW - United States
DO - 10.3201/eid2303.161916
UR - https://wwwnc.cdc.gov/eid/article/23/3/16-1916_article
ER - End of Reference