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Volume 23, Number 4—April 2017

Influence of Referral Pathway on Ebola Virus Disease Case-Fatality Rate and Effect of Survival Selection Bias

Frauke RudolfComments to Author , Mads Damkjær, Suzanne Lunding, Kenn Dornonville de la Cour, Alyssa Young, Tim Brooks, Tom Sesay, Alex P. Salam, Sharmistha Mishra, and Merete Storgaard
Author affiliations: Aarhus University Hospital, Skejby, Denmark (F. Rudolf, M. Storgaard); GOAL Global, Port Loko, Sierra Leone (M. Damkjær, S. Lunding, K.D. de la Cour, A. Young, A.P. Salam, M. Storgaard); Danish Armed Forces Health Services, Brabrand, Denmark (F. Rudolf, M. Damkjær, S. Lunding, K.D. de la Cour, M. Storgaard); Hans Christian Andersen Children’s Hospital, Odense, Denmark (M. Damkjær); Copenhagen University Hospital, Hillerod, Denmark (S. Lunding); Odense University Hospital, Odense (K.D. de la Cour); GOAL Global, Freetown, Sierra Leone (A. Young); Public Health England, Salisbury, UK (T. Brooks); Sierra Leone Ministry of Health and Sanitation, Freetown (T. Sesay); Wohl King’s College Clinical Neuroscience Institute, London, UK (A.P. Salam); University of Toronto St. Michael’s Hospital, Toronto, Ontario, Canada (S. Mishra)

Main Article


Demographic and epidemiologic differences between 2 patient cohorts in a study of the sources of variability in case-fatality rates in Ebola treatment centers, Sierra Leone, 2014–2016*

Variable Cohort 1, n = 48 Cohort 2, n = 78 p value
Case-fatality rate, % 46 67 0.02
Age, median, IQR 29 (14–40) 34 (20–45) 0.2
Children <15 years of age, no. (%) 12 (44) 15 (56) 0.4
Days from symptom onset to EVD testing (IQR) 4 (2–5) 4 (3–6) 0.7
Days from symptom onset to admission at ETC, median (IQR) 6 (4–7) 4 (2–5) <0.001
Ct, median (IQR)† 23 (21–26) 20 (18–23) <0.001

*Cohort 1 consisted of patients admitted directly to the ETC (Ebola treatment center) with confirmed EVD (Ebola virus disease); cohort 2 consisted of patients admitted directly to the ETC, where they were subsequently diagnosed with EVD. Ct, cycle threshold; IQR, interquartile range.
†Obtained from first blood sample drawn.

Main Article

Page created: March 16, 2017
Page updated: March 16, 2017
Page reviewed: March 16, 2017
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