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Volume 23, Number 4—April 2017
Research

Three Divergent Subpopulations of the Malaria Parasite Plasmodium knowlesi

Paul C.S. DivisComments to Author , Lee C. Lin, Jeffrine J. Rovie-Ryan, Khamisah A. Kadir, Fread Anderios, Shamilah Hisam, Reuben S.K. Sharma, Balbir Singh, and David J. Conway
Author affiliations: Malaria Research Centre, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia (P.C.S. Divis, K.A. Kadir, B. Singh, D.J. Conway); London School of Hygiene and Tropical Medicine, London, United Kingdom (P.C.S. Divis, D.J. Conway); Universiti Putra Malaysia, Serdang, Malaysia (L.C. Lin, R.S.K. Sharma); Department of Wildlife and National Parks Peninsular Malaysia, Kuala Lumpur, Malaysia (J.J. Rovie-Ryan); Sabah State Public Health Laboratory, Kota Kinabalu, Malaysia (F. Anderios); Institute for Medical Research, Kuala Lumpur (S. Hisam)

Main Article

Table

Summary of Plasmodium knowlesi mixed-genotype infections in 134 human and 48 macaque hosts across Malaysia obtained using 10 microsatellite loci*

Host and site
 Region
 No. samples
 No. isolates by no. genotypes detected
 % Poly
 Average MOI
 MS10
1
 2
 3
 4
Human
  Kapit Sarawak 35 27 5 2 1 23 1.34 35
  Betong Sarawak 4 4 0 0 0 0 1.00 3
  Lawas Sarawak 15 7 7 0 1 53 1.67 14
  Kudat Sabah 20 13 6 1 0 35 1.40 20
  Ranau Sabah 25 13 10 2 0 48 1.56 25
  Tenom Sabah 22 11 7 3 1 50 1.73 22
  Kelantan Peninsular Malaysia 13 5 6 2 0 62 1.77 13
Total
134
132
Long-tailed macaque
  Balingian Sarawak 1 0 1 0 0 100 2.00 1
  Limbang Sarawak 2 0 1 1 0 100 2.50 1
  Miri Sarawak 2 1 1 0 0 50 1.50 1
  Sarikei Sarawak 2 1 0 1 0 50 2.00 2
  Selangor Peninsular Malaysia 17 8 6 2 1 53 1.76 15
  Perak Peninsular Malaysia 6 1 3 2 0 83 2.17 5
  Negeri Sembilan Peninsular Malaysia 15 0 3 6 6 100 3.20 6
Total
 45
31
Pig-tailed macaque
  Limbang Sarawak 1 0 0 1 0 100 3.00 1
  Kapit Sarawak 2 1 0 1 0 50 2.00 2
Total 3 3
All 182 166

*All samples were successfully genotyped at ≥7 loci, and 166 samples had complete genotypes for all 10 microsatellite loci (MS10). MOI, multiplicity of infection; poly, polyclonal infections.

Main Article

Page created: March 17, 2017
Page updated: March 17, 2017
Page reviewed: March 17, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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