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Volume 23, Number 6—June 2017
Dispatch

Seoul Virus Infection in Humans, France, 2014–2016

Jean-Marc ReynesComments to Author , Damien Carli, Jean-Baptiste Bour, Samir Boudjeltia, Anny Dewilde, Guillaume Gerbier, Timothée Nussbaumer, Véronique Jacomo, Marie-Pierre Rapt, Pierre E. Rollin, and Alexandra Septfons
Author affiliations: Institut Pasteur, Lyon, France (J.-M. Reynes, D. Carli); Centre Hospitalier Universitaire Dijon-Bourgogne, Dijon, France (J.-B. Bour, S. Boudjeltia); Centre Hospitalier Universitaire Lille, Lille, France (A. Dewilde); Direction Départementale de la Cohésion Sociale et de la Protection des Populations, Colmar, France (G. Gerbier); Hôpitaux Civils de Colmar, Colmar (T. Nussbaumer); Biomnis, Lyon (V. Jacomo); Centre Hospitalier, Bar-le-Duc, France (M.-P. Rapt); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (P.E. Rollin); Santé Publique France, Saint-Maurice, France (A. Septfons)

Main Article

Table 2

Serologic results for hantaviruses for 3 patients with virologically confirmed infections with Seoul virus, France, 2014–2016*

Patient no. Day of sampling† First-line diagnostic test, commercial ELISA (index value)
 Diagnostic confirmation at NRC
 Additional test at NRC‡
ELISA
 IFA
IgM
 IgG
 Ig
 IgM
IgM IgG SEOV PUUV SEOV PUUV SEOV PUUV PUUV
1 3 +§ (4.3) +§ (1.9) + – – – – – –
2 5 +¶ (7.9) +¶ (>200) + – E – + E –
29 ND ND + E + E + – ND
3 4 +§ (11.8) +§ (9.8) + + E – + – –
80 ND ND + – + + + + ND

*E, equivocal; IFA, indirect fluorescent antibody; ND, not done; NRC, National Reference Center for Hantavirus (Lyon, France); PUUV, Puumala virus, SEOV, Seoul virus; +, positive; –, negative.
†No. days after symptom onset.
‡Reascan Rapid Test (Reagena, Toivala, Finland).
§Hantavirus IgG DxSelect and Hantavirus IgM DxSelect (Focus Diagnostics, Cypress, CA, USA).
¶Hantavirus Pool 1 Eurasia IgG and IgM (Euroimmun AG, Lübeck, Germany).

Main Article

Page created: May 16, 2017
Page updated: May 16, 2017
Page reviewed: May 16, 2017
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