Volume 23, Number 6—June 2017
Dispatch
Domestic Pig Unlikely Reservoir for MERS-CoV
Table
Comparison of the amino acid residues shown to be essential in binding of Middle East respiratory syndrome coronavirus spike protein to DPP4 of human, dromedary camel, and domestic pig*
Species |
DPP4, aa position | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
229 |
267 |
286 |
288 |
291 |
294 |
295 |
298 |
317 |
322 |
336 |
341 |
344 |
346 |
|
Human† |
N |
K |
Q |
T |
A |
L |
I |
H |
R |
Y |
R |
V |
Q |
I |
Dromedary camel‡ |
– |
– |
– |
V |
– |
– |
– |
– |
– |
– |
– |
– |
– |
– |
Domestic pig§ |
– |
– |
– |
V |
– |
– |
– |
– |
– |
– |
– |
– |
– |
– |
Mouse¶ | – | – | – | P | – | A | R | – | – | – | T | S | – | V |
*DPP4, dipeptidyl peptidase 4; –, no change from human DPP4.
†GenBank accession no. AB451339.
‡GenBank accession no. KF574263.
§GenBank accession no. NM214257.
¶Taken from previous publication (7).