TY - JOUR AU - Lother, Sylvain AU - Demczuk, Walter AU - Martin, Irene AU - Mulvey, Michael AU - Dufault, Brenden AU - Lagacé-Wiens, Philippe AU - Keynan, Yoav T1 - Clonal Clusters and Virulence Factors of Group C and G Streptococcus Causing Severe Infections, Manitoba, Canada, 2012–2014 T2 - Emerging Infectious Disease journal PY - 2017 VL - 23 IS - 7 SP - 1092 SN - 1080-6059 AB - The incidence of group C and G Streptococcus (GCGS) bacteremia, which is associated with severe disease and death, is increasing. We characterized clinical features, outcomes, and genetic determinants of GCGS bacteremia for 89 patients in Winnipeg, Manitoba, Canada, who had GCGS bacteremia during 2012–2014. Of the 89 patients, 51% had bacteremia from skin and soft tissue, 70% had severe disease features, and 20% died. Whole-genome sequencing analysis was performed on isolates derived from 89 blood samples and 33 respiratory sample controls: 5 closely related genetic lineages were identified as being more likely to cause invasive disease than non-clade isolates (83% vs. 57%, p = 0.002). Virulence factors cbp, fbp, speG, sicG, gfbA, and bca clustered clonally into these clades. A clonal distribution of virulence factors may account for severe and fatal cases of bacteremia caused by invasive GCGS. KW - Streptococcus dysgalactiae KW - group C streptococci KW - group G streptococci KW - invasive disease KW - bacteremia KW - virulence factor KW - genome sequencing KW - Canada KW - bacteria KW - group C Streptococcus KW - group G Streptococcus DO - 10.3201/eid2307.161259 UR - https://wwwnc.cdc.gov/eid/article/23/7/16-1259_article ER - End of Reference