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Volume 23, Number 7—July 2017
Dispatch

Rabbit Hepatitis E Virus Infections in Humans, France

Florence AbravanelComments to Author , Sébastien Lhomme, Hicham El Costa, Betoul Schvartz, Jean-Marie Peron, Nassim Kamar, and Jacques Izopet
Author affiliations: Centre de Physiopathologie de Toulouse Purpan, Toulouse, France (F. Abravanel, S. Lhomme, H. El Costa, N. Kamar, J. Izopet); Centre Hospitalier Universitaire de Toulouse, Toulouse (F. Abravanel, S. Lhomme, J.-M. Peron, N. Kamar, J. Izopet); Centre Hospitalier Universitaire de Reims, Reims, France (B. Schvartz)

Main Article

Figure

Phylogenetic tree for a 347-nt sequence within open reading frame 2 of hepatitis E viruses, France. Genetic distances were calculated by using the Kimura 2-parameter method, and the tree was plotted using the by the neighbor-joining method. Values along branches are bootstrap values acquired after 100 replications.  Virus sequences obtained from patients in this study (gray shading) were compared with reference sequences of subtypes 3 viruses according to the proposal of Smith et al. (3). GenBan

Figure. Phylogenetic tree for a 347-nt sequence within open reading frame 2 of hepatitis E viruses, France. Genetic distances were calculated by using the Kimura 2-parameter method, and the tree was plotted using the by the neighbor-joining method. Values along branches are bootstrap values acquired after 100 replications. Virus sequences obtained from patients in this study (gray shading) were compared with reference sequences of subtypes 3 viruses according to the proposal of Smith et al. (3). GenBank accession numbers, genotypes, and countries of origin are listed. Reference sequence in bold is from a hepatitis E virus genotype 3-ra isolated from a human. Scale bar indicates nucleotide substitutions per site.

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References
  1. Lhomme  S, Marion  O, Abravanel  F, Chapuy-Regaud  S, Kamar  N, Izopet  J. Pathogenesis. Viruses. 2016;8:E212. DOIPubMedGoogle Scholar
  2. Kamar  N, Dalton  HR, Abravanel  F, Izopet  J. Hepatitis E virus infection. Clin Microbiol Rev. 2014;27:11638. DOIPubMedGoogle Scholar
  3. Smith  DB, Simmonds  P, Izopet  J, Oliveira-Filho  EF, Ulrich  RG, Johne  R, et al. Proposed reference sequences for hepatitis E virus subtypes. J Gen Virol. 2016;97:53742. DOIPubMedGoogle Scholar
  4. Lhomme  S, Dubois  M, Abravanel  F, Top  S, Bertagnoli  S, Guerin  JL, et al. Risk of zoonotic transmission of HEV from rabbits. J Clin Virol. 2013;58:35762. DOIPubMedGoogle Scholar
  5. Caruso  C, Modesto  P, Prato  R, Scaglione  FE, De Marco  L, Bollo  E, et al. Hepatitis E virus: first description in a pet house rabbit. A new transmission route for human? Transbound Emerg Dis. 2015;62:22932. DOIPubMedGoogle Scholar
  6. Izopet  J, Dubois  M, Bertagnoli  S, Lhomme  S, Marchandeau  S, Boucher  S, et al. Hepatitis E virus strains in rabbits and evidence of a closely related strain in humans, France. Emerg Infect Dis. 2012;18:127481. DOIPubMedGoogle Scholar
  7. Abravanel  F, Sandres-Saune  K, Lhomme  S, Dubois  M, Mansuy  JM, Izopet  J. Genotype 3 diversity and quantification of hepatitis E virus RNA. J Clin Microbiol. 2012;50:897902. DOIPubMedGoogle Scholar
  8. Legrand-Abravanel  F, Mansuy  JM, Dubois  M, Kamar  N, Peron  JM, Rostaing  L, et al. Hepatitis E virus genotype 3 diversity, France. Emerg Infect Dis. 2009;15:1104. DOIPubMedGoogle Scholar
  9. Kamar  N, Rostaing  L, Legrand-Abravanel  F, Izopet  J. How should hepatitis E virus infection be defined in organ-transplant recipients? Am J Transplant. 2013;13:19356. DOIPubMedGoogle Scholar
  10. Mansuy  JM, Abravanel  F, Miedouge  M, Mengelle  C, Merviel  C, Dubois  M, et al. Acute hepatitis E in south-west France over a 5-year period. J Clin Virol. 2009;44:747. DOIPubMedGoogle Scholar
  11. Bouquet  J, Tessé  S, Lunazzi  A, Eloit  M, Rose  N, Nicand  E, et al. Close similarity between sequences of hepatitis E virus recovered from humans and swine, France, 2008-2009. Emerg Infect Dis. 2011;17:201825. DOIPubMedGoogle Scholar
  12. Lhomme  S, Abravanel  F, Dubois  M, Chapuy-Regaud  S, Sandres-Saune  K, Mansuy  JM, et al. Temporal evolution of the distribution of hepatitis E virus genotypes in Southwestern France. Infect Genet Evol. 2015;35:505. DOIPubMedGoogle Scholar
  13. Gallian  P, Lhomme  S, Piquet  Y, Sauné  K, Abravanel  F, Assal  A, et al. Hepatitis E virus infections in blood donors, France. Emerg Infect Dis. 2014;20:19147. DOIPubMedGoogle Scholar
  14. Mansuy  JM, Gallian  P, Dimeglio  C, Saune  K, Arnaud  C, Pelletier  B, et al. A nationwide survey of hepatitis E viral infection in French blood donors. Hepatology. 2016;63:114554. DOIPubMedGoogle Scholar
  15. Kamar  N, Izopet  J, Tripon  S, Bismuth  M, Hillaire  S, Dumortier  J, et al. Ribavirin for chronic hepatitis E virus infection in transplant recipients. N Engl J Med. 2014;370:111120. DOIPubMedGoogle Scholar

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The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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