TY - JOUR AU - Johansen, Cheryl AU - Williams, Simon AU - Melville, Lorna AU - Nicholson, Jay AU - Hall, Roy AU - Bielefeldt-Ohmann, Helle AU - Prow, Natalie AU - Chidlow, Glenys AU - Wong, Shani AU - Sinha, Rohini AU - Williams, David AU - Lipkin, W. Ian AU - Smith, David T1 - Characterization of Fitzroy River Virus and Serologic Evidence of Human and Animal Infection T2 - Emerging Infectious Disease journal PY - 2017 VL - 23 IS - 8 SP - 1289 SN - 1080-6059 AB - In northern Western Australia in 2011 and 2012, surveillance detected a novel arbovirus in mosquitoes. Genetic and phenotypic analyses confirmed that the new flavivirus, named Fitzroy River virus, is related to Sepik virus and Wesselsbron virus, in the yellow fever virus group. Most (81%) isolates came from Aedes normanensis mosquitoes, providing circumstantial evidence of the probable vector. In cell culture, Fitzroy River virus replicated in mosquito (C6/36), mammalian (Vero, PSEK, and BSR), and avian (DF-1) cells. It also infected intraperitoneally inoculated weanling mice and caused mild clinical disease in 3 intracranially inoculated mice. Specific neutralizing antibodies were detected in sentinel horses (12.6%), cattle (6.6%), and chickens (0.5%) in the Northern Territory of Australia and in a subset of humans (0.8%) from northern Western Australia. KW - novel flavivirus KW - Fitzroy River virus KW - arbovirus KW - Aedes normanensis KW - yellow fever virus group KW - whole-genome sequencing KW - viruses KW - Australia KW - United States DO - 10.3201/eid2308.161440 UR - https://wwwnc.cdc.gov/eid/article/23/8/16-1440_article ER - End of Reference