Figure 2. Analysis of the minor haplotype (H2) that caused recrudescence of Plasmodium malariae infection in a patient at Royal Darwin Hospital, Darwin, Northern Territory, Australia, March–April 2015, showing distribution of SNP alternative (nonreference) allele frequencies across the 14 chromosomes (boxes in the middle and dotted vertical lines) in the initial infection (bottom plot) and the recrudescence (top plot). The SNP colors (green, increasing in frequency; red, decreasing in frequency) form 2 clear bands, corresponding to H1 (yellow box) and H2 (pink box). H2 probably caused the recrudescence given that all of its alleles increase considerably in frequency. Colored boxes in center of chart indicate chromosome sharing. H1, haplotype 1; H2; haplotype 2; R1, reference genome; SNP, single-nucleotide polymorphism.