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Volume 23, Number 8—August 2017
Research

Clinical Laboratory Values as Early Indicators of Ebola Virus Infection in Nonhuman Primates

Ronald B. Reisler, Chenggang Yu, Michael J. Donofrio, Travis K. Warren, Jay B. Wells, Kelly S. Stuthman, Nicole L. Garza, Sean A. Vantongeren, Ginger C. Donnelly, Christopher D. Kane, Mark G. Kortepeter, Sina Bavari, and Anthony P. CardileComments to Author 
Author affiliations: United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA

Main Article

Figure 3

Survival curves, stratified by high (>9 log10 RNA copies/mL) and low (<9 log10 RNA copies/mL) viral loads, for each of 3 nonhuman primate models of Ebola virus disease. A) Comparison of survival on postinoculation day 5 for rhesus macaques infected with the Kikwit strain of Ebola virus (EBOV). Median survival time was 148.0 hours for macaques with high viral loads (n = 9) and 214.6 hours for macaques with low viral loads (n = 9). Comparison of the 2 survival curves yielded a statistically

Figure 3. Survival curves, stratified by high (>9 log10 RNA copies/mL) and low (<9 log10 RNA copies/mL) viral loads, for each of 3 nonhuman primate models of Ebola virus disease. A) Comparison of survival on postinoculation day 5 for rhesus macaques infected with the Kikwit strain of Ebola virus (EBOV). Median survival time was 148.0 hours for macaques with high viral loads (n = 9) and 214.6 hours for macaques with low viral loads (n = 9). Comparison of the 2 survival curves yielded a statistically significant value (p = 0.010 by Mantel-Cox log-rank test). B) Comparison of survival on postinoculation day 7 for rhesus macaques infected with the Makona strain of EBOV. Median survival time was 217.7 hours for macaques with high viral loads (n = 3) and 540.4 hours for macaques with low viral loads (n = 3). Comparison of the 2 survival curves yielded a statistically significant value (p = 0.025 by Mantel-Cox log-rank test). C) Comparison of survival on postinoculation day 5 for cynomolgus macaques infected with the Kikwit strain of EBOV. Median survival time was 170.6 hours for macaques with high viral loads (n = 4) and 195.0 hours for macaques with low viral loads (n = 2). Comparison of the 2 survival curves yielded a nearly statistically significant value (p = 0.074 by Gehan–Breslow–Wilcoxon test).

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Page created: July 17, 2017
Page updated: July 17, 2017
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