Volume 23, Number 8—August 2017
Clinical Laboratory Values as Early Indicators of Ebola Virus Infection in Nonhuman Primates
||Models of infection
|Rhesus macaque with||
||Cynomolgus macaque with Kikwit strain, n = 6
|Kikwit strain, n = 18
||Makona strain, n = 6
|Postchallenge clinical data|
|Survival time, h||186.9||337.5||0.005||175.2||0.739|
|Clinical responsiveness score, d§|
|Presence of petechial rash, d||5.65||8.17||<0.001||5.17||0.265|
|Decreased food consumption, d||5.11||8.33||<0.001||4.67||0.178|
|Presence of anuria, d||6.43||8.20||0.008||6.40||0.500|
*Data are means.
†For rhesus macaque model with Ebola virus (EBOV) Kikwit strain vs. Makona strain. Bold indicates p<0.05.
‡For rhesus macaque model with EBOV Kikwit strain vs. cynomolgus macaque model with EBOV Kikwit strain.
§Clinical Responsiveness Score: 0 = active, 1 = decreased activity; 2 = mildly unresponsive (becomes active when approached), occasional prostration; 3 = moderate unresponsiveness (may require prodding to respond), weakness; 4 = moderate to severe unresponsiveness (requires prodding), moderate prostration; 5 = moribund, severe unresponsiveness, pronounced prostration.