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Volume 23, Number 8—August 2017

Clinical Laboratory Values as Early Indicators of Ebola Virus Infection in Nonhuman Primates

Ronald B. Reisler, Chenggang Yu, Michael J. Donofrio, Travis K. Warren, Jay B. Wells, Kelly S. Stuthman, Nicole L. Garza, Sean A. Vantongeren, Ginger C. Donnelly, Christopher D. Kane, Mark G. Kortepeter, Sina Bavari, and Anthony P. CardileComments to Author 
Author affiliations: United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA

Main Article

Table 1

Baseline characteristics and clinical data for 3 nonhuman primate models of lethal Ebola virus disease*

Models of infection
Rhesus macaque with 
p value†
Cynomolgus macaque with Kikwit strain, n = 6
p value‡
Kikwit strain, n = 18
Makona strain, n = 6
Baseline characteristic
Weight, kg 4.92 4.79 0.894 4.44 0.526
Age, y
Postchallenge clinical data
Survival time, h 186.9 337.5 0.005 175.2 0.739
Clinical responsiveness score, d§
3 0 0 None 0 None
5 0.56 0 0.078 0.55 0.729
7 1.64 0.17 0.004 2.60 0.059
Presence of petechial rash, d 5.65 8.17 <0.001 5.17 0.265
Decreased food consumption, d 5.11 8.33 <0.001 4.67 0.178
Presence of anuria, d 6.43 8.20 0.008 6.40 0.500

*Data are means.
†For rhesus macaque model with Ebola virus (EBOV) Kikwit strain vs. Makona strain. Bold indicates p<0.05.
‡For rhesus macaque model with EBOV Kikwit strain vs. cynomolgus macaque model with EBOV Kikwit strain.
§Clinical Responsiveness Score: 0 = active, 1 = decreased activity; 2 = mildly unresponsive (becomes active when approached), occasional prostration; 3 = moderate unresponsiveness (may require prodding to respond), weakness; 4 = moderate to severe unresponsiveness (requires prodding), moderate prostration; 5 = moribund, severe unresponsiveness, pronounced prostration.

Main Article

Page created: July 17, 2017
Page updated: July 17, 2017
Page reviewed: July 17, 2017
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