Volume 23, Number 8—August 2017
Research
High Infection Rates for Adult Macaques after Intravaginal or Intrarectal Inoculation with Zika Virus
Andrew D. Haddow
, Aysegul Nalca, Franco D. Rossi, Lynn J. Miller, Michael R. Wiley, Unai Perez-Sautu, Samuel C. Washington, Sarah L. Norris, Suzanne E. Wollen-Roberts, Joshua D. Shamblin, Adrienne E. Kimmel, Holly A. Bloomfield, Stephanie M. Valdez, Thomas R. Sprague, Lucia M. Principe, Stephanie A. Bellanca, Stephanie S. Cinkovich, Luis Lugo-Roman, Lisa H. Cazares, William D. Pratt, Gustavo Palacios, Sina Bavari, M. Louise Pitt, and Farooq Nasar
, Aysegul Nalca, Franco D. Rossi, Lynn J. Miller, Michael R. Wiley, Unai Perez-Sautu, Samuel C. Washington, Sarah L. Norris, Suzanne E. Wollen-Roberts, Joshua D. Shamblin, Adrienne E. Kimmel, Holly A. Bloomfield, Stephanie M. Valdez, Thomas R. Sprague, Lucia M. Principe, Stephanie A. Bellanca, Stephanie S. Cinkovich, Luis Lugo-Roman, Lisa H. Cazares, William D. Pratt, Gustavo Palacios, Sina Bavari, M. Louise Pitt, and Farooq Nasar
Table 1
Serologic responses of 8 female rhesus and cynomolgus macaques after intravaginal inoculation of Zika virus*
| Macaque | Serologic response, PRNT80, by DPI |
|||
|---|---|---|---|---|
| 7 | 15 | 21 | 28 | |
| Rhesus 1 | – | 1:640 | 1:640 | 1:640 |
| Rhesus 2 | – | – | – | – |
| Rhesus 3 | – | – | – | – |
| Rhesus 4 | – | 1:640 | 1:640 | 1:640 |
| Cynomolgus 1 | – | – | – | – |
| Cynomolgus 2 | – | – | – | – |
| Cynomolgus 3 | – | 1:640 | 1:640 | 1:640 |
| Cynomolgus 4 | – | 1:1,280 | 1:1,280 | 1:1,280 |
*Values are titers. Limit of detection was a titer of 1:20. DPI, day postinoculation; PRNT80, 80% plaque reduction neutralization test; –, no detectable serologic response.
Page created: July 17, 2017
Page updated: July 17, 2017
Page reviewed: July 17, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.