Figure. Phylogenetic relationships between ferret coronaviruses (FrCoVs, shown in bold italics) and other known coronaviruses (CoVs). A) Complete genome; B) partial 3′-terminus genome. The nucleic acid sequence alignment was performed using ClustalX version 1.81 (http://www.clustal.org). The genetic distance was calculated by Kimura’s 2-parameter method. Phylogenetic trees with 1,000 bootstrap replicates were generated by the neighbor-joining method (Njplot 2.3, http://njplot.sharewarejunction.com/). Comparison CoVs identified by GenBank accession number. Scale bars indicate substitutions per site.