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Volume 23, Number 9—September 2017

Myocarditis Caused by Human Parechovirus in Adult

Khai Lin KongComments to Author , Jillian S.Y. Lau, Su Mei Goh, Heather L. Wilson, Mike Catton, and Tony M. Korman
Author affiliations: Monash University, Clayton, Victoria, Australia (K.L. Kong, J.S.Y. Lau, S.M. Goh, T.M. Korman); Monash Health, Clayton (K.L. Kong, J. Lau, S.M. Goh, T.M. Korman); Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia (H.L. Wilson, M. Catton)

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Characteristics of 5 patients with myocarditis caused by infection with human parechovirus*

Patient (reference) Age/sex Underlying disease Clinical features Sample in which virus was detected Subtype Echocardiographic finding Therapy Outcome
1 (11) NA/M NA NA Stool, blood 1† NA NA NA
2 (13) 14 mo/M Congenital AGG Myocarditis Myocardium, pericardial fluid 1† NA None Died
3 (14) 6 wk/M None Myocarditis Stool 1† NA None Survived
4 (12) 16 y/F SLE, rituximab-induced HGG Myocarditis, encephalitis Myocardium, CSF, stool 3 Biventricular dysfunction, LVEF 13% IVIG Survived, prolonged neurologic recovery
5 (this study) 26 y/M None Myocarditis Throat swab specimen Unknown Dilated left ventricle, LVEF 15% None Survived, Well at 6-mo follow up

*AGG, agammaglobulinemia; CSF, cerebrospinal fluid; HGG, hypogammaglobulinemia; IVIG, intravenous immunoglobulin; LVEF, left ventricular ejection fraction; NA, not available; SLE, systemic lupus erythematosus.
†Previously known as echovirus subtype 22.

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Page created: August 17, 2017
Page updated: August 17, 2017
Page reviewed: August 17, 2017
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