Volume 23, Number 9—September 2017
Research
Processes Underlying Rabies Virus Incursions across US–Canada Border as Revealed by Whole-Genome Phylogeography
Figure 3

Figure 3. Locations of sequenced samples from Canada outbreaks of raccoon-specific variant of rabies virus infection in western Ontario (n = 1), eastern Ontario (n = 56), Quebec (n = 51), and New Brunswick (n = 32); and from the United States within 75 km of the border in western New York (n = 23), northwestern New York (n = 29, including 5 samples into clade I, indicated by squares), and Vermont (n = 64, including 2 samples from New York that grouped within this clade, indicated by squares); and from throughout Maine (n = 33). Map generated by using ggmap package (20). NB, New Brunswick; ON, Ontario; QC, Quebec.
References
- Wandeler AI, Rosatte RC, Williams D, Lee TK, Gensheimer KF, Montero JT, et al.; Centers for Disease Control and Prevention (CDC). Update: raccoon rabies epizootic—United States and Canada, 1999. MMWR Morb Mortal Wkly Rep. 2000;49:31–5.PubMedGoogle Scholar
- Sterner RT, Meltzer MI, Shwiff SA, Slate D. Tactics and economics of wildlife oral rabies vaccination, Canada and the United States. Emerg Infect Dis. 2009;15:1176–84. DOIPubMedGoogle Scholar
- Moore DA. Spatial diffusion of raccoon rabies in Pennsylvania, USA. Prev Vet Med. 1999;40:19–32. DOIPubMedGoogle Scholar
- Wilson ML, Bretsky PM, Cooper GH Jr, Egbertson SH, Van Kruiningen HJ, Cartter ML. Emergence of raccoon rabies in Connecticut, 1991-1994: spatial and temporal characteristics of animal infection and human contact. Am J Trop Med Hyg. 1997;57:457–63. DOIPubMedGoogle Scholar
- Lucey BT, Russell CA, Smith D, Wilson ML, Long A, Waller LA, et al. Spatiotemporal analysis of epizootic raccoon rabies propagation in Connecticut, 1991-1995. Vector Borne Zoonotic Dis. 2002;2:77–86. DOIPubMedGoogle Scholar
- Biek R, Henderson JC, Waller LA, Rupprecht CE, Real LA. A high-resolution genetic signature of demographic and spatial expansion in epizootic rabies virus. Proc Natl Acad Sci U S A. 2007;104:7993–8. DOIPubMedGoogle Scholar
- Stevenson B, Goltz J, Massé A. Preparing for and responding to recent incursions of raccoon rabies variant into Canada. Can Commun Dis Rep. 2016;42:125–9 [cited 2017 Jun 22]. http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/16vol42/dr-rm42-6/assets/pdf/16vol42_6-ar-03-eng.pdf
- Rosatte RC, Donovan D, Allan M, Bruce L, Buchanan T, Sobey K, et al. The control of raccoon rabies in Ontario Canada: proactive and reactive tactics, 1994-2007. J Wildl Dis. 2009;45:772–84. DOIPubMedGoogle Scholar
- Rosatte R, MacDonald E, Sobey K, Donovan D, Bruce L, Allan M, et al. The elimination of raccoon rabies from Wolfe Island, Ontario: animal density and movements. J Wildl Dis. 2007;43:242–50. DOIPubMedGoogle Scholar
- Shwiff S, Aenishaenslin C, Ludwig A, Berthiaume P, Bigras-Poulin M, Kirkpatrick K, et al. Bioeconomic modelling of raccoon rabies spread management impacts in Quebec, Canada. Transbound Emerg Dis. 2013;60:330–7. DOIPubMedGoogle Scholar
- Nadin-Davis SA, Colville A, Trewby H, Biek R, Real L. Application of high-throughput sequencing to whole rabies viral genome characterisation and its use for phylogenetic re-evaluation of a raccoon strain incursion into the province of Ontario. Virus Res. 2017;232:123–33. DOIPubMedGoogle Scholar
- Drummond AJ, Ho SYW, Phillips MJ, Rambaut A. Relaxed phylogenetics and dating with confidence. PLoS Biol. 2006;4:e88. DOIPubMedGoogle Scholar
- Lemey P, Rambaut A, Drummond AJ, Suchard MA. Bayesian phylogeography finds its roots. PLOS Comput Biol. 2009;5:e1000520. DOIPubMedGoogle Scholar
- Drummond AJ, Suchard MA, Xie D, Rambaut A. Bayesian phylogenetics with BEAUti and the BEAST 1.7. Mol Biol Evol. 2012;29:1969–73. DOIPubMedGoogle Scholar
- Ayres DL, Darling A, Zwickl DJ, Beerli P, Holder MT, Lewis PO, et al. BEAGLE: an application programming interface and high-performance computing library for statistical phylogenetics. Syst Biol. 2012;61:170–3. DOIPubMedGoogle Scholar
- Bielejec F, Rambaut A, Suchard MA, Lemey P. SPREAD: spatial phylogenetic reconstruction of evolutionary dynamics. Bioinformatics. 2011;27:2910–2. DOIPubMedGoogle Scholar
- Minin VN, Suchard MA. Fast, accurate and simulation-free stochastic mapping. Philos Trans R Soc Lond B Biol Sci. 2008;363:3985–95. DOIPubMedGoogle Scholar
- Szanto AG, Nadin-Davis SA, Rosatte RC, White BN. Genetic tracking of the raccoon variant of rabies virus in eastern North America. Epidemics. 2011;3:76–87. DOIPubMedGoogle Scholar
- Nadin-Davis SA, Muldoon F, Wandeler AI. A molecular epidemiological analysis of the incursion of the raccoon strain of rabies virus into Canada. Epidemiol Infect. 2006;134:534–47. DOIPubMedGoogle Scholar
- Kahle D, Wickham H. ggmap: spatial visualization with ggplot2. The R Journal. 2013;5:144–61 [cited 2017 June 22]. http://journal.r-project.org/archive/2013-1/kahle-wickham.pdf
- MacInnes C. Raccoon rabies in New Brunswick. Rabies report. Peterborough (Ontario, Canada); Ontario Ministry of Natural Resources; 2000; vol. 11. p. 10.
- Henderson JC, Biek R, Hanlon CA, O’Dee S, Real LA. Rabies virus in raccoons, Ohio, 2004. Emerg Infect Dis. 2008;14:650–2. DOIPubMedGoogle Scholar
- Cullingham CI, Pond BA, Kyle CJ, Rees EE, Rosatte RC, White BN. Combining direct and indirect genetic methods to estimate dispersal for informing wildlife disease management decisions. Mol Ecol. 2008;17:4874–86. DOIPubMedGoogle Scholar
- Dharmarajan G, Beasley JC, Fike JA, Rhodes OE. Population genetic structure of raccoons (Procyon lotor) inhabiting a highly fragmented landscape. Can J Zool. 2009;87:814–24. DOIGoogle Scholar
- Rosatte R, Ryckman M, Ing K, Proceviat S, Allan M, Bruce L, et al. Density, movements, and survival of raccoons in Ontario, Canada: implications for disease spread and management. J Mammal. 2010;91:122–35. DOIGoogle Scholar
- Rosatte R, Sobey K, Donovan D, Bruce L, Allan M, Silver A, et al. Behavior, movements, and demographics of rabid raccoons in Ontario, Canada: management implications. J Wildl Dis. 2006;42:589–605. DOIPubMedGoogle Scholar
- Rosatte R, Sobey K, Donovan D, Allan M, Bruce L, Buchanan T, et al. Raccoon density and movements after population reduction to control rabies. J Wildl Manage. 2007;71:2373–8. DOIGoogle Scholar
- Rosatte R, Donovan D, Allan M, Howes LA, Silver A, Bennett K, et al. Emergency response to raccoon rabies introduction into Ontario. J Wildl Dis. 2001;37:265–79. DOIPubMedGoogle Scholar
- Nettles VF, Shaddock JH, Sikes RK, Reyes CR. Rabies in translocated raccoons. Am J Public Health. 1979;69:601–2. DOIPubMedGoogle Scholar