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Volume 23, Number 9—September 2017

Microcephaly Caused by Lymphocytic Choriomeningitis Virus

Maia DelaineComments to Author , Anne-Sophie Weingertner, Antoine Nougairede, Quentin Lepiller, Samira Fafi-Kremer, Romain Favre, and Rémi N. Charrel
Author affiliations: Hôpitaux Universitaires de Strasbourg, Strasbourg, France (M. Delaine, A.-S. Weingertner, Q. Lepiller, S. Fafi-Kremer, R. Favre); Aix-Marseille University, Marseille, France (A. Nougairede, R. Charrel); Public Hospitals of Marseille, Marseille (A. Nougairede, R. Charrel)

Main Article


Characteristics of neonates with congenital viral or bacterial infections, including a fetus with congenital microencephaly caused by infection with LCMV in a 29-year-old pregnant women at 23 weeks’ gestation*

Virus infection or disease VM Intracranial hypertension Calcification Microcephaly Retinopathy Hearing impairment HSM Nonimmune anasarca Fetal growth restriction
LCMV +++ + ++++ +++ +++ ? ?† + ?‡
Toxoplasmosis + + ++ + +++ + ++ + +
Rubella virus + ± + + +++ +++ ± +
CMV + + +++ + +++ +++ + +
HSV + + + + + + +
Syphilis ± + + + +++ + +
Parvovirus B19 + ++ +
Zika virus§ ++ + + +++ + ? ? + ++

*Data were obtained from Anderson et al. (2) and Barton and Mets (3). CMV, cytomegalovirus; HSM, hepatomegaly/splenomegaly; HSV, herpes simplex virus; LCMV, lymphocytic choriomeningitis virus; VM, ventriculomegaly. –, not observed; ±, possibly observed; +, rarely observed; ++, sometimes observed; +++, frequently observed; ++++, constantly observed; ?, not known.
†Diagnosed only by postmortem examination (8; this study).
‡Reported by Bonthius (14) in 6 of 20 neonates.
§Reported by Alvarado and Schwartz (4).

Main Article

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Page created: August 17, 2017
Page updated: August 17, 2017
Page reviewed: August 17, 2017
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