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Volume 24, Number 1—January 2018
Dispatch

Two-Center Evaluation of Disinfectant Efficacy against Ebola Virus in Clinical and Laboratory Matrices

Sophie J. Smither, Lin Eastaugh, Claire Marie Filone, Denise Freeburger, Artemas Herzog, M. Stephen Lever, David M. Miller, Dana Mitzel, James W. Noah, Mary S. Reddick-Elick, Amy Reese, Michael Schuit, Carly B. Wlazlowski, Michael Hevey, and Victoria Wahl-JensenComments to Author 
Author affiliations: Defence Science and Technology Laboratory, Porton Down, UK (S.J. Smither, L. Eastaugh, M.S. Lever); National Biodefense Analysis and Countermeasures Center, Frederick, Maryland, USA (C.M. Filone, D. Freeburger, D.M. Miller, D. Mitzel, J.W. Noah, M.S. Reddick-Elick, A. Reese, M. Schuit, C.B. Wlazlowski, M. Hevey, V. Wahl-Jensen); Censeo Consulting Group, Seattle, Washington, USA (A. Herzog)

Main Article

Table 2

NBACC studies of evaluation of 6 disinfectants for reducing Ebola virus titers in dry blood or cell culture medium*

Disinfectant and volume, µL
 Dried blood Dried cell culture medium
Mean log10 TCID50 (SD) disinfected
Mean log10 TCID50 (SD) control
log difference
 t-test p value
 Mean log10 TCID50 (SD) disinfected
Mean log10 TCID50 (SD) control
log difference
 t-test p value
Purell Advanced, 30 3.1 (0.2) 2.6 (0.3) <0 9.5 × 10–1 0.7 (0) 2.4 (0.3) 1.7 5.6 × 10–3
Steriplex SD, 100 2.4 (0.2) 3.0 (0.2) 0.6 8.8 × 10–3 0.7 (0) 3.3 (0.2) 2.6 5.9 × 10–4
Micro-Chem Plus, 30 2.8 (0.5) 3.4 (0.5) 0.6 4.9 × 10–2 0.7 (0) 1.5 (0.2) 0.8 3.6 × 10–5
Micro-Chem Plus, 100 1.5 (0.1) 2.9 (0.2) 1.4 1.4 × 10–4 ND ND ND ND
Bleach, 30 2.2 (0.5) 3.1 (0.1) 0.9 1.1 × 10–3 0.7 (0) 2.7 (0.2) 2.0 1.3 × 10–3
Acidified bleach, 100 1.7 (0.3) 2.7 (0.3) 1.1 5.9 × 10–3 0.7 (0) 2.6 (0.2) 1.9 2.0 × 10–3
Peracetic acid, 100 0.7 (0) 2.7 (0.3) 2.0 4.3 × 10–3 0.7 (0) 1.9 (0.4) 1.2 7.8 × 10–2

*NBACC, National Biodefense Analysis and Countermeasures Center; ND, no data; TCID50, 50% tissue culture infectious dose.

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Page created: December 19, 2017
Page updated: December 19, 2017
Page reviewed: December 19, 2017
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