TY - JOUR AU - Fernandez-Garcia, Maria Dolores AU - Majumdar, Manasi AU - Kebe, Ousmane AU - Fall, Aichatou AU - Kone, Moussa AU - Kande, Mouctar AU - Dabo, Moustapha AU - Sylla, Mohamed Salif AU - Sompare, Djenou AU - Howard, Wayne AU - Faye, Ousmane AU - Martin, Javier AU - Ndiaye, Kader T1 - Emergence of Vaccine-Derived Polioviruses during Ebola Virus Disease Outbreak, Guinea, 2014–2015 T2 - Emerging Infectious Disease journal PY - 2018 VL - 24 IS - 1 SP - 65 SN - 1080-6059 AB - During the 2014–2015 outbreak of Ebola virus disease in Guinea, 13 type 2 circulating vaccine-derived polioviruses (cVDPVs) were isolated from 6 polio patients and 7 healthy contacts. To clarify the genetic properties of cVDPVs and their emergence, we combined epidemiologic and virologic data for polio cases in Guinea. Deviation of public health resources to the Ebola outbreak disrupted polio vaccination programs and surveillance activities, which fueled the spread of neurovirulent VDPVs in an area of low vaccination coverage and immunity. Genetic properties of cVDPVs were consistent with their capacity to cause paralytic disease in humans and capacity for sustained person-to-person transmission. Circulation ceased when coverage of oral polio vaccine increased. A polio outbreak in the context of the Ebola virus disease outbreak highlights the need to consider risks for polio emergence and spread during complex emergencies and urges awareness of the challenges in polio surveillance, vaccination, and diagnosis. KW - vaccine-derived poliovirus KW - Ebola outbreak KW - acute flaccid paralysis KW - viruses KW - Guinea KW - vaccines KW - vaccination DO - 10.3201/eid2401.171174 UR - https://wwwnc.cdc.gov/eid/article/24/1/17-1174_article ER - End of Reference