Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 24, Number 10—October 2018
Research

Zika Virus Infection during Pregnancy and Effects on Early Childhood Development, French Polynesia, 2013–2016

Lorenzo Subissi, Timothée Dub, Marianne Besnard, Teheipuaura Mariteragi-Helle, Tuxuan Nhan, Delphine Lutringer-Magnin, Philippe Barboza, Céline Gurry, Pauline Brindel, Eric J. Nilles, David Baud, Angela Merianos, Didier Musso, Judith R. Glynn, Gilles Dupuis, Van-Mai Cao-Lormeau1, Marine Giard1Comments to Author , and Henri-Pierre Mallet1
Author affiliations: World Health Organization, Geneva, Switzerland (L. Subissi, P. Barboza, C. Gurry, P. Brindel); Institut Pasteur, Paris, France (T. Dub); French Polynesia Hospital Center, Pirae, French Polynesia (M. Besnard, D. Lutringer-Magnin); Institut Louis Malardé, Papeete, French Polynesia (T. Mariteragi-Helle, T. Nhan, D. Musso, V.-M. Cao-Lormeau); Brigham and Women’s Hospital and Harvard Humanitarian Initiative, Boston, Massachusetts, USA (E.J. Nilles); World Health Organization, Manila, Philippines (E.J. Nilles, A. Merianos); University Hospital, Lausanne, Switzerland (D. Baud); Aix Marseille University, IRD, AP-HM, SSA, VITROME, IHU-Méditerranée Infection, Marseille, France (D. Musso); London School of Hygiene & Tropical Medicine, London, UK (J.R. Glynn); University of Québec, Montreal, Québec, Canada (G. Dupuis); Centre de Liaison sur l’Intervention et la Prévention Psychosociales, Montreal (G. Dupuis); Bureau de Veille Sanitaire, Direction de la Santé, Papeete (M. Giard, H.-P. Mallet)

Main Article

Table 2

Characteristics and comparison of case-patients and controls in study of Zika virus infection during pregnancy and early childhood development, French Polynesia, 2013–2016*

Characteristics Cases, n = 21 Controls, n = 102 p value†
Mother’s age at pregnancy, median (IQR) 26.8 (22.1–35.7) 27.8 (22.2–33.7) NA
15–24 8 (38) 37 (36) NA
25–34 7 (33) 43 (42) NA
>35
 6 (29)
 22 (22)
 NA
Estimated pregnancy start date, median (IQR) 2013 Dec 11 
(2013 Oct 23–2014 May 9) 2013 Dec 8 
(2013 Oct 16–2014 May 16)
January–September 2013 4 (19) 19 (19) NA
October 2013–December 2014 9 (43) 43 (42)
January–April 2014 2 (9) 10 (10)
May–August 2014
 6 (29)
 30 (29)
Maternal socioeconomic status
Low 9 (43) 34 (34) 0.52
Middle 4 (19) 31 (31)
High
 8 (38)
 36 (36)
Child’s birthweight, g n = 11 n = 100
<1,500 0 2 (2)
1,500–2,500 3 (27) 9 (9)
>2,500
 8 (73)
 89 (89)
Child’s sex
F 10 (48) 42 (41) 0.64
M
 11 (52)
 60 (59)
Child’s ethnicity
Polynesian 14 (74) 61 (71) 0.56
Caucasian 2 (11) 2 (2)
Mixed/other
 3 (16)
 23 (27)
Pregnancy outcome
Termination of pregnancy 10 (48) NA NA
Gestational age at termination of pregnancy, median (IQR) 25.5 (23–29) NA NA
Live birth 11 (52) 102 (100) NA
Gestational age at child’s birth, median (IQR) 39 (36–40) 39 (38–40) 0.23
Term, >37 weeks 8 (73) 85 (83)
Premature, 27–36 weeks
 3 (27)
 17 (17)
Mother’s past infection with dengue viruses
DENV-1 seropositivity 17 (81) 88 (87) 0.50
DENV-2 seropositivity 12 (57) 50 (50) 0.54
DENV-3 seropositivity 16 (76) 78 (77) 0.99
DENV-4 seropositivity
 10 (48)
 52 (51)
 0.74
Other risk factors/confounders
Family history of congenital abnormalities 6 (29) 24 (25) 0.84
Drug use during pregnancy‡ 9 (45) 34 (33) 0.23
Deltamethrin outdoor spraying during pregnancy 10 (48) 50 (51) 0.73

*Values are no. (%) except as indicated. IQR, interquartile range; NA, not applicable.
†Likelihood ratio using conditional logistic regression.
‡Cannabis, cocaine, alcohol, or tobacco.

Main Article

1These authors contributed equally to this article.

Page created: September 16, 2018
Page updated: September 16, 2018
Page reviewed: September 16, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external