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Volume 24, Number 10—October 2018

Zika Virus Infection during Pregnancy and Effects on Early Childhood Development, French Polynesia, 2013–2016

Lorenzo Subissi, Timothée Dub, Marianne Besnard, Teheipuaura Mariteragi-Helle, Tuxuan Nhan, Delphine Lutringer-Magnin, Philippe Barboza, Céline Gurry, Pauline Brindel, Eric J. Nilles, David Baud, Angela Merianos, Didier Musso, Judith R. Glynn, Gilles Dupuis, Van-Mai Cao-Lormeau1, Marine Giard1Comments to Author , and Henri-Pierre Mallet1
Author affiliations: World Health Organization, Geneva, Switzerland (L. Subissi, P. Barboza, C. Gurry, P. Brindel); Institut Pasteur, Paris, France (T. Dub); French Polynesia Hospital Center, Pirae, French Polynesia (M. Besnard, D. Lutringer-Magnin); Institut Louis Malardé, Papeete, French Polynesia (T. Mariteragi-Helle, T. Nhan, D. Musso, V.-M. Cao-Lormeau); Brigham and Women’s Hospital and Harvard Humanitarian Initiative, Boston, Massachusetts, USA (E.J. Nilles); World Health Organization, Manila, Philippines (E.J. Nilles, A. Merianos); University Hospital, Lausanne, Switzerland (D. Baud); Aix Marseille University, IRD, AP-HM, SSA, VITROME, IHU-Méditerranée Infection, Marseille, France (D. Musso); London School of Hygiene & Tropical Medicine, London, UK (J.R. Glynn); University of Québec, Montreal, Québec, Canada (G. Dupuis); Centre de Liaison sur l’Intervention et la Prévention Psychosociales, Montreal (G. Dupuis); Bureau de Veille Sanitaire, Direction de la Santé, Papeete (M. Giard, H.-P. Mallet)

Main Article

Table 3

Crude and adjusted OR for congenital central nervous system abnormalities and maternal Zika virus infection status, French Polynesia, 2013–2016*

Exposures Case-patients, no. (%) Controls, no. (%) Matched crude OR (95% CI) Matched adjusted OR† (95% CI) LRT 
p value
Zika virus seropositivity
20 (95)
78 (76)
6.02 (0.77–47.1)
7.07 (0.86–58.3)
Reported Zika virus infection
No infection during pregnancy‡ 1 (5) 24 (24) 1 1 0.04
Asymptomatic (timing unknown)§ 12 (57) 61 (60) 2.05 (0.54–7.80) 1.93 (0.47–7.96)
Symptomatic during pregnancy¶ 8 (38) 17 (17) 6.79 (1.36–33.8) 7.19 (1.39–37.2)

*LRT, likelihood ratio test; NA, not applicable; OR, odds ratio.
†Adjusted for maternal socioeconomic status.
‡Seronegative mothers and seropositive mothers who reported Zika-like illness outside pregnancy.
§Seropositive mothers who did not report Zika-like illness during or outside pregnancy.
¶Seropositive mothers who reported Zika-like illness during pregnancy.

Main Article

1These authors contributed equally to this article.

Page created: September 16, 2018
Page updated: September 16, 2018
Page reviewed: September 16, 2018
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